Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 2/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.43 |
| ▸ | TYMS | P04818 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | NT5E | P21589 | 2/20 | 0.37 |
| ▸ | HBB | P68871 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.36 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.36 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7646628 | 0.88 | POLB (0.51) | DNMT1ADRB1SLC29A1TYMSPOLB | |
| SCHEMBL7644531 | 0.83 | SLC29A1 (0.56) | SLC29A1POLBNT5E | |
| SCHEMBL1152839 | 0.80 | SLC29A1 (0.51) | DNMT1ADRB1SLC29A1TYMSHBB | |
| SCHEMBL1152834 | 0.80 | SLC29A1 (0.51) | DNMT1ADRB1SLC29A1TYMSHBB | |
| SCHEMBL10064053 | 0.77 | DNMT1 (0.70) | DNMT1ADRB1POLBNT5EHBB | |
| SCHEMBL19283452 | 0.74 | DNMT1 (0.76) | DNMT1ADRB1POLBNT5EHBB | |
| SCHEMBL7643482 | 0.74 | P2RY2 (0.38) | SLC29A1TYMSPOLBNT5EP2RY2 | |
| SCHEMBL7027958 | 0.74 | POLB (0.57) | SLC29A1TYMSPOLBNT5EHBB | |
| SCHEMBL10064225 | 0.74 | DNMT1 (0.74) | DNMT1ADRB1POLBNT5EHBB | |
| SCHEMBL16366026 | 0.74 | DNMT1 (0.74) | DNMT1ADRB1POLBNT5EHBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234223-A1 | N4 MODIFICATIONS OF PYRIMIDINE ANALOGS AND USES THEREOF | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234223-A1 | N4 MODIFICATIONS OF PYRIMIDINE ANALOGS AND USES THEREOF | TYMP, TYMS, DPYD | DNMT1 465/4885ADRB1 4599/4885SLC29A1 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.