Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | HTT | P42858 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 3/20 | 0.39 |
| ▸ | SKP1 | P63208 | 3/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4069078 | 0.94 | RPS6KA5 (0.46) | RPS6KA5AKT1RPS6KA1SMN1; SMN2MAPT | |
| SCHEMBL14031568 | 0.91 | RPS6KA5 (0.47) | RPS6KA5AKT1RPS6KA1SMN1; SMN2MAPT | |
| SCHEMBL4070921 | 0.87 | SMN1; SMN2 (0.39) | RPS6KA5AKT1RPS6KA1SMN1; SMN2MAPT | |
| SCHEMBL5058547 | 0.84 | CKS1B (0.50) | RPS6KA5AKT1RPS6KA1SMN1; SMN2MAPT | |
| SCHEMBL5597414 | 0.82 | TP53 (0.41) | TP53KDM4EHTTCKS1BSKP1 | |
| SCHEMBL14031474 | 0.82 | AKT1 (0.45) | RPS6KA5AKT1RPS6KA1SMN1; SMN2MAPT | |
| SCHEMBL4064408 | 0.80 | RPS6KA5 (0.66) | RPS6KA5AKT1RPS6KA1KDM4ESLC2A1 | |
| SCHEMBL4389658 | 0.78 | HTT (0.41) | RPS6KA5AKT1RPS6KA1SMN1; SMN2MAPT | |
| SCHEMBL14031597 | 0.78 | SLC2A1 (0.52) | RPS6KA5AKT1RPS6KA1MAPTTP53 | |
| SCHEMBL14031559 | 0.78 | SLC2A1 (0.43) | RPS6KA5AKT1RPS6KA1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080255143-A1 | Inhibitors of Akt Activity | SMITHKLINE BEECHAM CORPORATION (PA) | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255143-A1 | Inhibitors of Akt Activity | PI4KB, PIK3CA, AKT2 | RPS6KA5 156/4885AKT1 5/4885RPS6KA1 127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.