Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 17/20 | 0.43 |
| ▸ | BACE2 | Q9Y5Z0 | 8/20 | 0.43 |
| ▸ | CTSD | P07339 | 6/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.34 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.34 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.34 |
| ▸ | CYP2A7 | P20853 | 1/20 | 0.34 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.34 |
| ▸ | CYP2F1 | P24903 | 1/20 | 0.34 |
| ▸ | CYP2C18 | P33260 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5069197 | 0.86 | BACE1 (0.40) | BACE1BACE2CTSDCYP1A1CYP1A2 | |
| SCHEMBL5067184 | 0.85 | BACE1 (0.39) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL5063558 | 0.85 | BACE1 (0.37) | BACE1BACE2CTSDCYP1A1CYP1A2 | |
| SCHEMBL5069130 | 0.85 | BACE1 (0.42) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL4520245 | 0.82 | BACE1 (0.46) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL4734194 | 0.78 | BACE1 (0.35) | BACE1BACE2CTSDSLC22A12 | |
| SCHEMBL5067256 | 0.77 | BACE1 (0.39) | BACE1BACE2CTSDKCNH2CYP3A4 | |
| SCHEMBL5063659 | 0.76 | BACE1 (0.40) | BACE1BACE2CTSDKCNH2CYP3A4 | |
| SCHEMBL5140925 | 0.76 | BACE1 (0.40) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL4526211 | 0.75 | BACE1 (0.77) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979324-A2 | NOVEL 2-AMINO-IMIDAZOLE-4-ONE COMPOUNDS AND THEIR USE IN THE MANUFACTURE OF A MEDICAMENT TO BE USED IN THE TREATMENT OF COGNITIVE IMPAIRMENT, ALZHEIMER'S DISEASE, NEURODEGENERATION AND DEMENTIA | Astra Zeneca AB (SE) | 2008-10-15 | — | — | EP | claimed |
| WO-2007058602-A2 | NOVEL 2-AMINO-IMIDAZOLE-4-ONE COMPOUNDS AND THEIR USE IN THE MANUFACTURE OF A MEDICAMENT TO BE USED IN THE TREATMENT OF COGNITIVE IMPAIRMENT, ALZHEIMER’S DISEASE, NEURODEGENERATION AND DEMENTIA. | ASTRAZENECA AB (SE) | 2007-05-24 | — | — | WO | claimed |