Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.70 |
| ▸ | CDK1 | P06493 | 1/20 | 0.56 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.55 |
| ▸ | CSF1R | P07333 | 2/20 | 0.55 |
| ▸ | TYK2 | P29597 | 2/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.55 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.55 |
| ▸ | STK16 | O75716 | 1/20 | 0.55 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.55 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.55 |
| ▸ | ULK3 | Q6PHR2 | 1/20 | 0.55 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.55 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.55 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5066746 | 0.85 | EGFR (0.74) | EGFRCDK1 | |
| SCHEMBL14461569 | 0.85 | EGFR (0.76) | EGFR | |
| SCHEMBL13672658 | 0.83 | EGFR (0.79) | EGFR | |
| SCHEMBL13675165 | 0.83 | EGFR (0.71) | EGFR | |
| SCHEMBL13672602 | 0.83 | EGFR (0.87) | EGFR | |
| SCHEMBL5067329 | 0.82 | EGFR (1.00) | EGFRCDK1JAK2JAK3 | |
| SCHEMBL13675243 | 0.82 | EGFR (0.77) | EGFR | |
| SCHEMBL14461354 | 0.81 | EGFR (0.69) | EGFR | |
| SCHEMBL5063878 | 0.81 | EGFR (1.00) | EGFRCDK1 | |
| SCHEMBL13672633 | 0.80 | EGFR (1.00) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912639-A2 | THIAZOLOPYRIMIDINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007019191-A2 | THIAZOLOPYRIMIDINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-02-15 | — | — | WO | disclosed |