Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 14/20 | 0.80 |
| ▸ | CACNA1I | Q9P0X4 | 13/20 | 0.60 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.54 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.54 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.54 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.52 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2885977 | 0.89 | KCNH2 (1.00) | KCNH2CACNA1ICACNA1HCACNA1GCHRM2 | |
| SCHEMBL2890373 | 0.83 | KCNH2 (0.88) | KCNH2CACNA1ICACNA1HCACNA1GCHRM2 | |
| SCHEMBL2886970 | 0.83 | KCNH2 (0.88) | KCNH2CACNA1ICACNA1HCACNA1GCHRM2 | |
| SCHEMBL2885545 | 0.83 | KCNH2 (0.88) | KCNH2CACNA1ICACNA1HCACNA1GCHRM2 | |
| SCHEMBL2889559 | 0.81 | KCNH2 (0.83) | KCNH2CACNA1ICACNA1HCACNA1GCHRM2 | |
| SCHEMBL2887401 | 0.79 | KCNH2 (0.80) | KCNH2CACNA1ICACNA1HCACNA1GCHRM2 | |
| SCHEMBL2882537 | 0.79 | KCNH2 (0.80) | KCNH2CACNA1ICACNA1HCACNA1GCHRM2 | |
| SCHEMBL2887407 | 0.79 | KCNH2 (0.80) | KCNH2CACNA1ICACNA1HCACNA1GCHRM2 | |
| SCHEMBL2890404 | 0.78 | KCNH2 (0.67) | KCNH2CACNA1ICACNA1HCACNA1GCHRM2 | |
| SCHEMBL18838437 | 0.77 | CACNA1I (0.68) | KCNH2CACNA1ICACNA1HCACNA1GCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1901746-A2 | 4-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS | Merck & Co., Inc. (US) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007002884-A2 | 4-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK & CO., INC. (US) | 2007-01-04 | — | — | WO | disclosed |