Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 4/20 | 0.54 |
| ▸ | GSK3B | P49841 | 2/20 | 0.54 |
| ▸ | DKK1 | O94907 | 1/20 | 0.54 |
| ▸ | CHUK | O15111 | 1/20 | 0.53 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.53 |
| ▸ | CDK1 | P06493 | 2/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.48 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 6/20 | 0.47 |
| ▸ | CDK4 | P11802 | 5/20 | 0.47 |
| ▸ | PLK1 | P53350 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2194717 | 0.86 | ABL1 (0.58) | IKBKBGSK3BCHUKIKBKGCDK1 | |
| SCHEMBL12423205 | 0.83 | IKBKB (0.52) | IKBKBGSK3BDKK1CHUKIKBKG | |
| SCHEMBL14140151 | 0.83 | AKT3 (0.60) | IKBKBCHUKIKBKGCDK1CDK2 | |
| SCHEMBL2195564 | 0.81 | MKNK1 (0.56) | IKBKBGSK3BCHUKIKBKGCAMK2D | |
| SCHEMBL27666312 | 0.81 | AKT3 (0.65) | AKT3 | |
| SCHEMBL3089691 | 0.80 | AURKB (0.57) | IKBKBGSK3BDKK1CHUKIKBKG | |
| SCHEMBL12423171 | 0.79 | IKBKB (0.55) | IKBKBGSK3BDKK1CDK1CCNB2 | |
| SCHEMBL3097167 | 0.79 | IKBKB (0.55) | IKBKBGSK3BCHUKIKBKGCDK2 | |
| SCHEMBL12423686 | 0.78 | IKBKB (0.52) | IKBKBGSK3BCHUKIKBKGCDK1 | |
| SCHEMBL11889664 | 0.77 | KDM4E (0.55) | AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948647-A1 | PYRIMIDINYL-THIOPHENE KINASE MODULATORS | SGX Pharmaceuticals, Inc. (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007053776-A1 | PYRIMIDINYL-THIOPHENE KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2007-05-10 | — | — | WO | disclosed |