Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5071693 | 0.94 | NPC1 (0.39) | NPC1KCNH2CACNA1GALDH1A1POLB | |
| SCHEMBL5069860 | 0.87 | KCNH2 (0.41) | KCNH2CACNA1G | |
| SCHEMBL5069843 | 0.84 | CACNA1H (0.40) | KCNH2CACNA1G | |
| SCHEMBL2886010 | 0.76 | NPC1 (0.46) | NPC1KCNH2CACNA1GTSHRMAPT | |
| SCHEMBL2890369 | 0.71 | KCNH2 (0.50) | NPC1KCNH2CACNA1G | |
| SCHEMBL4274547 | 0.70 | KMT2A (0.47) | NPC1KCNH2CACNA1GALDH1A1POLB | |
| SCHEMBL4274552 | 0.70 | KMT2A (0.47) | NPC1KCNH2CACNA1GALDH1A1POLB | |
| SCHEMBL14708779 | 0.70 | NPC1 (0.53) | NPC1KCNH2CACNA1GTSHRHPGD | |
| SCHEMBL4279685 | 0.66 | CACNA1I (0.49) | NPC1KCNH2CACNA1GALDH1A1POLB | |
| SCHEMBL4270883 | 0.66 | CACNA1I (0.49) | NPC1KCNH2CACNA1GALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1901746-A2 | 4-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS | Merck & Co., Inc. (US) | 2008-03-26 | — | — | EP | claimed |
| WO-2007002884-A2 | 4-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK & CO., INC. (US) | 2007-01-04 | — | — | WO | claimed |