Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.86 |
| ▸ | CTSD | P07339 | 3/20 | 0.77 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.77 |
| ▸ | APP | P05067 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4234572 | 1.00 | BACE1 (0.86) | BACE1CTSDBACE2APP | |
| Trifluoroacetic Acid SCHEMBL4232214 | 0.93 | BACE1 (0.73) | BACE1CTSDBACE2 | |
| SCHEMBL4233968 | 0.93 | BACE1 (1.00) | BACE1CTSDBACE2APP | |
| SCHEMBL5067087 | 0.93 | BACE1 (1.00) | BACE1CTSDBACE2APP | |
| SCHEMBL4240953 | 0.92 | BACE1 (0.86) | BACE1CTSDBACE2APP | |
| SCHEMBL8238344 | 0.89 | BACE1 (0.88) | BACE1CTSDBACE2APP | |
| SCHEMBL8239023 | 0.88 | BACE1 (0.86) | BACE1CTSDBACE2APP | |
| SCHEMBL8238086 | 0.87 | BACE1 (0.80) | BACE1CTSDBACE2 | |
| SCHEMBL4232605 | 0.87 | BACE1 (1.00) | BACE1CTSDBACE2 | |
| SCHEMBL4315221 | 0.87 | BACE1 (1.00) | BACE1CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954682-A1 | NOVEL 2-AMINO-IMIDAZOLE-4-ONE COMPOUNDS AND THEIR USE IN THE MANUFACTURE OF A MEDICAMENT TO BE USED IN THE TREATMENT OF COGNITIVE IMPAIRMENT, ALZHEIMER S DISEASE, NEURODEGENERATION AND DEMENTIA | Astra Zeneca AB (SE) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007058601-A1 | NOVEL 2-AMINO-IMIDAZOLE-4-ONE COMPOUNDS AND THEIR USE IN THE MANUFACTURE OF A MEDICAMENT TO BE USED IN THE TREATMENT OF COGNITIVE IMPAIRMENT, ALZHEIMER’S DISEASE, NEURODEGENERATION AND DEMENTIA | ASTRAZENECA AB (SE) | 2007-05-24 | — | — | WO | disclosed |