Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 5/20 | 0.61 |
| ▸ | SYK | P43405 | 1/20 | 0.58 |
| ▸ | GSK3B | P49841 | 5/20 | 0.54 |
| ▸ | CDK7 | P50613 | 5/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.54 |
| ▸ | LCK | P06239 | 4/20 | 0.54 |
| ▸ | GSK3A | P49840 | 4/20 | 0.54 |
| ▸ | JAK2 | O60674 | 4/20 | 0.54 |
| ▸ | BTK | Q06187 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 6/20 | 0.48 |
| ▸ | AURKA | O14965 | 4/20 | 0.48 |
| ▸ | ABL1 | P00519 | 4/20 | 0.48 |
| ▸ | FLT3 | P36888 | 4/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.48 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.48 |
| ▸ | PAK4 | O96013 | 3/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.48 |
| ▸ | FYN | P06241 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5067895 | 0.92 | IGF1R (0.64) | IGF1RSYKGSK3BCDK7AURKB | |
| SCHEMBL1779860 | 0.89 | SYK (0.60) | IGF1RSYKGSK3BCDK7AURKB | |
| SCHEMBL12605859 | 0.89 | IGF1R (0.58) | IGF1RSYKGSK3BCDK7AURKB | |
| SCHEMBL1779221 | 0.89 | IGF1R (0.58) | IGF1RSYKGSK3BCDK7AURKB | |
| SCHEMBL1777705 | 0.88 | IGF1R (0.59) | IGF1RSYKGSK3BCDK7AURKB | |
| SCHEMBL12605817 | 0.88 | IGF1R (0.59) | IGF1RSYKGSK3BCDK7AURKB | |
| SCHEMBL1780543 | 0.86 | IGF1R (0.60) | IGF1RSYKGSK3BCDK7AURKB | |
| SCHEMBL1777168 | 0.86 | IGF1R (0.74) | IGF1RSYKGSK3BCDK7AURKB | |
| SCHEMBL1778517 | 0.84 | SYK (0.59) | IGF1RSYKGSK3BCDK7AURKB | |
| SCHEMBL1778685 | 0.84 | SYK (0.59) | IGF1RSYKGSK3BCDK7AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1990343-A2 | Azaindoles | Aventis Pharma Limited (GB) | 2008-11-12 | — | — | EP | disclosed |