Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT3 | Q9Y243 | 17/20 | 0.55 |
| ▸ | IKBKB | O14920 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2198523 | 0.84 | AKT3 (0.47) | AKT3IKBKBABL1BCRSRC | |
| SCHEMBL14500316 | 0.79 | AKT3 (0.52) | AKT3ABL1BCRSRC | |
| SCHEMBL12423209 | 0.79 | AKT3 (0.56) | AKT3IKBKB | |
| SCHEMBL2200857 | 0.79 | SRC (0.47) | AKT3IKBKBABL1BCRSRC | |
| SCHEMBL12423200 | 0.79 | AKT3 (0.61) | AKT3IKBKB | |
| SCHEMBL5068267 | 0.78 | IKBKB (0.44) | AKT3IKBKBABL1BCRSRC | |
| SCHEMBL13051469 | 0.78 | AKT3 (0.49) | AKT3ABL1BCRSRC | |
| SCHEMBL12423373 | 0.78 | AKT3 (0.71) | AKT3IKBKBABL1BCRSRC | |
| SCHEMBL14100342 | 0.78 | AKT3 (0.51) | AKT3IKBKBABL1BCRSRC | |
| SCHEMBL12423662 | 0.78 | AKT3 (0.61) | AKT3ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948647-A1 | PYRIMIDINYL-THIOPHENE KINASE MODULATORS | SGX Pharmaceuticals, Inc. (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007053776-A1 | PYRIMIDINYL-THIOPHENE KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2007-05-10 | — | — | WO | disclosed |