Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Quetiapine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 4/20 | 0.85 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.85 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.85 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.85 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.85 |
| ▸ | DRD3 | P35462 | 3/20 | 0.85 |
| ▸ | DRD4 | P21917 | 2/20 | 0.85 |
| ▸ | LMNA | P02545 | 2/20 | 0.85 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.85 |
| ▸ | HTR1A | P08908 | 2/20 | 0.85 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.85 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.85 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.85 |
| ▸ | DRD1 | P21728 | 2/20 | 0.85 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.85 |
| ▸ | HRH1 | P35367 | 2/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quetiapine SCHEMBL29487500 | 1.00 | KDM4E (1.00) | KDM4EMEN1MAPK1KMT2ADRD2 | |
| Quetiapine SCHEMBL122596 | 1.00 | KDM4E (1.00) | KDM4EMEN1MAPK1KMT2ADRD2 | |
| Quetiapine SCHEMBL31678628 | 1.00 | KDM4E (1.00) | KDM4EMEN1MAPK1KMT2ADRD2 | |
| Quetiapine SCHEMBL4962023 | 1.00 | KDM4E (1.00) | KDM4EMEN1MAPK1KMT2ADRD2 | |
| Quetiapine SCHEMBL41336 | 1.00 | KDM4E (1.00) | KDM4EMEN1MAPK1KMT2ADRD2 | |
| Quetiapine SCHEMBL390694 | 1.00 | KDM4E (1.00) | KDM4EMEN1MAPK1KMT2ADRD2 | |
| Quetiapine SCHEMBL30990390 | 1.00 | KDM4E (1.00) | KDM4EMEN1MAPK1KMT2ADRD2 | |
| Quetiapine SCHEMBL5325208 | 1.00 | KDM4E (1.00) | KDM4EMEN1MAPK1KMT2ADRD2 | |
| Quetiapine SCHEMBL678457 | 1.00 | KDM4E (1.00) | KDM4EMEN1MAPK1KMT2ADRD2 | |
| Quetiapine SCHEMBL41338 | 1.00 | KDM4E (1.00) | KDM4EMEN1MAPK1KMT2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9993486-B1 | Oral quetiapine suspension formulations with extended shelf life and enhanced bioavailability | TLC THERAPEUTICS, LLC (US) | 2018-06-12 | — | — | US | disclosed |
| EP-1758600-A4 | METHODS AND COMPOSITIONS FOR TREATING MOOD DISORDER | MOOD MAN SCIENCES LLC (US) | 2008-03-05 | — | — | EP | disclosed |
| EP-1758600-A1 | METHODS AND COMPOSITIONS FOR TREATING MOOD DISORDER | Mood Management Sciences, LLC (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005120523-A1 | METHODS AND COMPOSITIONS FOR TREATING MOOD DISORDER | MOOD MANAGEMENT SCIENCES, LLC (US) | 2005-12-22 | — | — | WO | disclosed |