Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | GFER | P55789 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5066641 | 1.00 | HTT (0.48) | HTTMAPTHPGDALDH1A1POLB | |
| SCHEMBL5066636 | 1.00 | HTT (0.48) | HTTMAPTHPGDALDH1A1POLB | |
| SCHEMBL5069146 | 0.87 | POLB (0.44) | HTTMAPTHPGDALDH1A1POLB | |
| SCHEMBL5068231 | 0.85 | MAPT (0.40) | HTTMAPTHPGDALDH1A1POLB | |
| SCHEMBL5071761 | 0.85 | MAPT (0.40) | HTTMAPTHPGDALDH1A1POLB | |
| SCHEMBL5070804 | 0.85 | POLB (0.40) | HTTMAPTHPGDALDH1A1POLB | |
| SCHEMBL5068233 | 0.85 | MAPT (0.40) | HTTMAPTHPGDALDH1A1POLB | |
| SCHEMBL5069179 | 0.85 | POLB (0.40) | HTTMAPTHPGDALDH1A1POLB | |
| SCHEMBL5069177 | 0.85 | POLB (0.40) | HTTMAPTHPGDALDH1A1POLB | |
| SCHEMBL5068725 | 0.81 | TSHR (0.42) | HTTMAPTHPGDALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1653947-B1 | (4-HYDROXYPHENYL)-1H-INDOLE-3-CARBALDEHYDE OXIME DERIVATIVES AS ESTROGENIC AGENTS | WYETH CORP (US) | 2008-01-16 | — | — | EP | claimed |