Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 12/20 | 0.53 |
| ▸ | EGLN2 | Q96KS0 | 15/20 | 0.44 |
| ▸ | THRA | P10827 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | CSF1R | P07333 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3782146 | 0.90 | EGLN1 (0.66) | EGLN1EGLN2THRATHRB | |
| SCHEMBL5070942 | 0.89 | EGLN2 (0.42) | EGLN1EGLN2CSF1R | |
| SCHEMBL3779142 | 0.81 | EGLN1 (0.57) | EGLN1EGLN2 | |
| SCHEMBL30274573 | 0.81 | EGLN1 (0.56) | EGLN1EGLN2 | |
| SCHEMBL522188 | 0.81 | EGLN1 (0.56) | EGLN1EGLN2 | |
| SCHEMBL1219877 | 0.79 | EGLN1 (0.69) | EGLN1EGLN2THRATHRB | |
| SCHEMBL3786716 | 0.73 | EGLN1 (0.60) | EGLN1EGLN2 | |
| SCHEMBL523651 | 0.73 | EGLN1 (0.66) | EGLN1EGLN2THRATHRB | |
| SCHEMBL522758 | 0.72 | EGLN1 (0.84) | EGLN1EGLN2THRATHRB | |
| SCHEMBL523124 | 0.72 | EGLN1 (1.00) | EGLN1EGLN2THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893186-A2 | IMPROVED TREATMENT FOR ANEMIA USING A HIF-ALPHA STABILISING AGENT | FIBROGEN, INC. (US) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006133391-A2 | IMPROVED TREATMENT FOR ANEMIA USING A HIF-ALPHA STABILISING AGENT | FIBROGEN, INC. (US) | 2006-12-14 | — | — | WO | disclosed |