Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 15/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 9/20 | 0.51 |
| ▸ | FLT3 | P36888 | 4/20 | 0.51 |
| ▸ | KIT | P10721 | 2/20 | 0.51 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.46 |
| ▸ | FLT4 | P35916 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4965829 | 0.87 | PDGFRB (0.62) | PDGFRBPDGFRAFLT3KITENPP1 | |
| SCHEMBL4968153 | 0.85 | PDGFRB (0.58) | PDGFRBPDGFRAFLT3KITENPP1 | |
| SCHEMBL4966832 | 0.74 | PDGFRB (0.71) | PDGFRBPDGFRAFLT3KITENPP1 | |
| SCHEMBL4965795 | 0.72 | PDGFRB (0.66) | PDGFRBPDGFRAFLT3KITENPP1 | |
| SCHEMBL4966763 | 0.72 | ENPP1 (0.71) | PDGFRBPDGFRAFLT3KITENPP1 | |
| SCHEMBL4973701 | 0.71 | MAPK7 (0.60) | PDGFRBPDGFRAFLT3KITENPP1 | |
| SCHEMBL4972356 | 0.71 | PDGFRB (0.66) | PDGFRBPDGFRAFLT3KITENPP1 | |
| SCHEMBL14599423 | 0.70 | PDGFRB (0.59) | PDGFRBPDGFRAFLT3KITKDR | |
| SCHEMBL2920107 | 0.70 | PDGFRB (0.83) | PDGFRBPDGFRAFLT3KIT | |
| SCHEMBL5072193 | 0.70 | PDGFRB (0.58) | PDGFRBPDGFRAFLT3KITKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893206-A2 | SYNERGISTIC MODULATION OF FLT3 KINASE USING AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006135636-A2 | SYNERGISTIC MODULATION OF FLT3 KINASE USING AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-21 | — | — | WO | disclosed |