Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 17/20 | 0.48 |
| ▸ | BACE2 | Q9Y5Z0 | 8/20 | 0.48 |
| ▸ | APP | P05067 | 3/20 | 0.48 |
| ▸ | CTSD | P07339 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5069585 | 0.90 | BACE1 (0.47) | BACE1BACE2APPCTSD | |
| SCHEMBL5069575 | 0.88 | BACE1 (0.50) | BACE1BACE2APPCTSD | |
| SCHEMBL5070589 | 0.86 | BACE1 (0.55) | BACE1BACE2APPCTSD | |
| SCHEMBL5071289 | 0.85 | BACE1 (0.49) | BACE1BACE2APPCTSD | |
| SCHEMBL5069591 | 0.83 | BACE1 (0.59) | BACE1BACE2APPCTSD | |
| SCHEMBL5069586 | 0.83 | BACE1 (0.59) | BACE1BACE2APPCTSD | |
| SCHEMBL3419002 | 0.83 | BACE1 (0.50) | BACE1BACE2APPCTSD | |
| SCHEMBL5072992 | 0.82 | BACE1 (0.49) | BACE1BACE2APP | |
| SCHEMBL5073000 | 0.82 | BACE1 (0.58) | BACE1BACE2APPCTSD | |
| SCHEMBL5072997 | 0.80 | BACE1 (0.58) | BACE1BACE2APPCTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685142-B1 | PHOSPHINIC ACID DERIVATIVES, BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | claimed |