Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 11/20 | 0.46 |
| ▸ | APP | P05067 | 3/20 | 0.46 |
| ▸ | CTRC | Q99895 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5071380 | 0.94 | BACE1 (0.50) | BACE1APPCTRCCTSDACACB | |
| SCHEMBL5073996 | 0.92 | BACE1 (0.53) | BACE1APPCTRCCTSDBACE2 | |
| SCHEMBL5069586 | 0.88 | BACE1 (0.59) | BACE1APPCTSDBACE2 | |
| SCHEMBL5069591 | 0.88 | BACE1 (0.59) | BACE1APPCTSDBACE2 | |
| SCHEMBL5072997 | 0.83 | BACE1 (0.58) | BACE1APPCTSDBACE2 | |
| SCHEMBL5073997 | 0.83 | BACE1 (0.58) | BACE1APPCTSDBACE2 | |
| SCHEMBL5071306 | 0.83 | BACE1 (0.58) | BACE1APPCTSDBACE2 | |
| SCHEMBL5073000 | 0.83 | BACE1 (0.58) | BACE1APPCTSDBACE2 | |
| SCHEMBL3434792 | 0.81 | BACE1 (0.49) | BACE1APPCTSDACACBLMNA | |
| SCHEMBL5074005 | 0.81 | BACE1 (0.46) | BACE1APPACACBLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685142-B1 | PHOSPHINIC ACID DERIVATIVES, BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | claimed |