SCHEMBL5074558

SCHEMBL5074558

COC(C)=C(C(=O)O)c1ccccc1COc1cc(Cl)c(OC(F)(F)C(F)F)c(Cl)c1

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MRGPRX4 Q96LA9 5/20 0.37
HTT P42858 2/20 0.37
TP53 P04637 1/20 0.37
MAOA P21397 2/20 0.36
MAOB P27338 2/20 0.36
HIF1A Q16665 5/20 0.36
MEN1 O00255 1/20 0.35
ALDH1A1 P00352 1/20 0.35
LMNA P02545 1/20 0.35
HPGD P15428 1/20 0.35
KMT2A Q03164 1/20 0.35
NR4A2 P43354 2/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
SCN9A Q15858 1/20 0.35
OPRL1 P41146 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5074514 0.94 MRGPRX4 (0.36) MRGPRX4HTTTP53MAOAMAOB
SCHEMBL5074555 0.92 TP53 (0.38) MRGPRX4HTTTP53MAOAMAOB
SCHEMBL5074501 0.92 HIF1A (0.35) MRGPRX4HTTTP53MAOAMAOB
SCHEMBL5074512 0.86 TP53 (0.37) MRGPRX4HTTTP53MAOAMAOB
SCHEMBL5074500 0.84 TP53 (0.35) MRGPRX4HTTTP53MAOAMAOB
SCHEMBL6149505 0.83 TP53 (0.36) MRGPRX4HTTTP53MAOAMAOB
SCHEMBL6150542 0.83 HIF1A (0.48) MRGPRX4HTTTP53MAOAMAOB
SCHEMBL6150541 0.83 HIF1A (0.48) MRGPRX4HTTTP53MAOAMAOB
SCHEMBL6149508 0.83 TP53 (0.36) MRGPRX4HTTTP53MAOAMAOB
SCHEMBL5080372 0.83 OPRL1 (0.44) MRGPRX4MAOAMAOBHIF1AOPRL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7435844-B2 Analogous compounds of strobilurines and their use as acaricides and insecticides ISAGRO RICERCA S.R.L. (IT) 2008-10-14 US disclosed
US-20060235075-A1 Analogous compounds of strobilurines and their use as acaricides and insecticides ISAGRO RICERCA S.R.L. (IT) 2006-10-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060235075-A1 Analogous compounds of strobilurines and their use as acaricides and insecticides DDT, RYR1, TPMT MRGPRX4 989/4885HTT 4420/4885TP53 2842/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.