SCHEMBL5074575

SCHEMBL5074575

CNC(=O)C(=NOC)c1ccccc1COc1cc(Cl)c(OC)c(Cl)c1

nearest known ligand 0.53

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 8/20 0.53
HTT P42858 2/20 0.40
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
ALDH1A1 P00352 1/20 0.40
LMNA P02545 1/20 0.40
HPGD P15428 1/20 0.40
MRGPRX4 Q96LA9 2/20 0.40
TP53 P04637 1/20 0.37
MAOA P21397 1/20 0.36
MAOB P27338 1/20 0.36
POLB P06746 1/20 0.36
MAPT P10636 1/20 0.36
MAPK1 P28482 1/20 0.36
HDAC8 Q9BY41 1/20 0.35
BCL2 P10415 1/20 0.35
MCL1 Q07820 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5074571 1.00 HIF1A (0.53) HIF1AHTTMEN1KMT2AALDH1A1
SCHEMBL5076414 0.92 HIF1A (0.52) HIF1AHTTMEN1KMT2AALDH1A1
SCHEMBL5076406 0.92 HIF1A (0.52) HIF1AHTTMEN1KMT2AALDH1A1
SCHEMBL5076508 0.90 HIF1A (0.50) HIF1AHTTMEN1KMT2AALDH1A1
SCHEMBL5080514 0.90 HIF1A (0.50) HIF1AHTTMEN1KMT2AMRGPRX4
SCHEMBL5079524 0.90 HIF1A (0.61) HIF1AMEN1KMT2AALDH1A1LMNA
SCHEMBL5074541 0.90 HIF1A (0.50) HIF1AHTTMEN1KMT2AALDH1A1
SCHEMBL5076507 0.90 HIF1A (0.50) HIF1AHTTMEN1KMT2AALDH1A1
SCHEMBL5074546 0.90 HIF1A (0.50) HIF1AHTTMEN1KMT2AALDH1A1
SCHEMBL5080511 0.90 HIF1A (0.50) HIF1AHTTMEN1KMT2AMRGPRX4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7435844-B2 Analogous compounds of strobilurines and their use as acaricides and insecticides ISAGRO RICERCA S.R.L. (IT) 2008-10-14 US disclosed
US-20060235075-A1 Analogous compounds of strobilurines and their use as acaricides and insecticides ISAGRO RICERCA S.R.L. (IT) 2006-10-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060235075-A1 Analogous compounds of strobilurines and their use as acaricides and insecticides DDT, RYR1, TPMT HIF1A 4554/4885HTT 4420/4885MEN1 2918/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.