Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 16/20 | 0.73 |
| ▸ | EGLN2 | Q96KS0 | 12/20 | 0.59 |
| ▸ | THRA | P10827 | 3/20 | 0.53 |
| ▸ | THRB | P10828 | 3/20 | 0.53 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | ASPH | Q12797 | 1/20 | 0.52 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.52 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15268881 | 0.90 | EGLN2 (0.74) | EGLN1EGLN2 | |
| SCHEMBL15268813 | 0.86 | EGLN2 (0.75) | EGLN1EGLN2 | |
| SCHEMBL30274563 | 0.84 | EGLN1 (0.76) | EGLN1EGLN2THRATHRBBBOX1 | |
| SCHEMBL522006 | 0.84 | EGLN1 (0.76) | EGLN1EGLN2THRATHRBBBOX1 | |
| SCHEMBL29726484 | 0.84 | EGLN1 (1.00) | EGLN1EGLN2THRATHRBBBOX1 | |
| SCHEMBL523124 | 0.84 | EGLN1 (1.00) | EGLN1EGLN2THRATHRBBBOX1 | |
| SCHEMBL15268608 | 0.84 | EGLN1 (0.49) | EGLN1EGLN2 | |
| SCHEMBL523101 | 0.83 | EGLN2 (0.71) | EGLN1EGLN2THRATHRBFTO | |
| SCHEMBL1219109 | 0.79 | EGLN1 (0.65) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL523170 | 0.79 | EGLN1 (0.84) | EGLN1EGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893186-A2 | IMPROVED TREATMENT FOR ANEMIA USING A HIF-ALPHA STABILISING AGENT | FIBROGEN, INC. (US) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006133391-A2 | IMPROVED TREATMENT FOR ANEMIA USING A HIF-ALPHA STABILISING AGENT | FIBROGEN, INC. (US) | 2006-12-14 | — | — | WO | disclosed |