SCHEMBL507698

SCHEMBL507698

CC(=O)c1sccc1Br

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Thiosemicarbazide SCHEMBL2782322 0.84 POLB (0.43)
SCHEMBL399760 0.79
SCHEMBL11193772 0.78 POLB (0.56)
SCHEMBL13809683 0.78 GAA (0.51)
SCHEMBL1623886 0.77
SCHEMBL621972 0.77
SCHEMBL318317 0.77 KMT2A (0.54)
SCHEMBL15979697 0.76 IDO1 (0.49)
SCHEMBL7045346 0.76 POLB (0.49)
SCHEMBL18719416 0.76 POLB (0.73)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 112 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117486872-A Mechanical ball milling synthesis method of aminothiazole compound 浙江工业大学 2024-02-02 CN claimed
CN-117486872-A Mechanical ball milling synthesis method of aminothiazole compound 浙江工业大学 2024-02-02 CN disclosed
WO-2023215494-A1 THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF ERASCA, INC. (US) 2023-11-09 WO disclosed
US-11718607-B2 Atypical coupling method for the preparation of 1,2-di(thiophen-2-yl)ethene-1,2-diol compounds via a Cu(II) catalyst QATAR UNIVERSITY (QA) 2023-08-08 US disclosed
WO-2023116763-A1 PYRIDAZINE COMPOUND, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF 上海优理惠生医药有限公司 2023-06-29 WO disclosed
US-20230129899-A1 COMPOUND, PHOTOSENSITIZER COMPRISING SAME, COMPOSITION FOR DIAGNOSING OR TREATING TUMOR TARGETING MITOCHONDRIA, AND PHOTODYNAMIC TREATMENT METHOD USING COMPOSITION KYTECBIO CO., LTD. (KR) 2023-04-27 US disclosed
US-20230129899-A1 COMPOUND, PHOTOSENSITIZER COMPRISING SAME, COMPOSITION FOR DIAGNOSING OR TREATING TUMOR TARGETING MITOCHONDRIA, AND PHOTODYNAMIC TREATMENT METHOD USING COMPOSITION KYTECBIO CO., LTD. (KR) 2023-04-27 US disclosed
CN-114249667-A Method for preparing N-H ketoamide by using tert-butoxide as catalyst and by using two-step one-pot reaction 衡阳师范学院 2022-03-29 CN disclosed
US-20210387964-A1 HETEROARYLAMINOQUINOLINES AND ANALOGUES BAYER AKTIENGESELLSCHAFT (DE) 2021-12-16 US disclosed
EP-3399968-B1 SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE CS PHARMATECH LTD (KY) 2021-10-20 EP disclosed
US-7241779-B2 Fused pyrrolocarbazoles CEPHALON, INC. (US) 2007-07-10 US disclosed
US-20070155804-A1 Mitotic kinesin inhibitor KYOWA HAKKO KOGYO CO., LTD. OF TOKYO, JAPAN FUJI PHOTO FILM CO., LTD. KANAGAWA, JAPAN 2007-07-05 US disclosed
CN-1934088-A As 5-HT2c6-substituted 2,3,4, 5-tetrahydro-1H-benzo [ d ] receptor agonists]Aza * LILLY CO ELI (US) 2007-03-21 CN disclosed
EP-1720836-A1 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO [D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS ELI LILLY AND COMPANY (US) 2006-11-15 EP disclosed
WO-2006066172-A1 AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE AMGEN, INC. (US) 2006-06-22 WO disclosed
US-20060074113-A1 Thiadiazoline derivative KYOWA KIRIN CO., LTD. (JP) 2006-04-06 US disclosed
EP-1616866-A1 M-STAGE KINESIN INHIBITOR KYOWA HAKKO KOGYO CO., LTD. (JP) 2006-01-18 EP disclosed
WO-2005082859-A1 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS ELI LILLY AND COMPANY (US) 2005-09-09 WO disclosed
WO-2005063764-A2 FUSED PYRROLOCARBAZOLES AND METHODS FOR THE PREPARATION THEREOF CEPHALON, INC. (US) 2005-07-14 WO disclosed
EP-1454903-A1 THIADIAZOLINE DERIVATIVE KYOWA HAKKO KOGYO CO., LTD. (JP) 2004-09-08 EP disclosed