Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 known ✓ | P08173 | 1/20 | 0.41 |
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 0.41 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.41 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.64 |
| ▸ | CA2 | P00918 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | EEF2K | O00418 | 2/20 | 0.44 |
| ▸ | EEF2 | P13639 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | ITK | Q08881 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL574665 | 1.00 | CA1 (0.64) | CA1CA2KMT2AMEN1EEF2K | |
| Bromide SCHEMBL1330666 | 1.00 | CA1 (0.64) | CA1CA2KMT2AMEN1EEF2K | |
| Bromide SCHEMBL707780 | 1.00 | CA1 (0.64) | CA1CA2KMT2AMEN1EEF2K | |
| Bromide SCHEMBL1330853 | 1.00 | CA1 (0.64) | CA1CA2KMT2AMEN1EEF2K | |
| Bromide SCHEMBL15329258 | 1.00 | CA1 (0.64) | CA1CA2KMT2AMEN1EEF2K | |
| Bromide SCHEMBL3835039 | 1.00 | CA1 (0.64) | CA1CA2KMT2AMEN1EEF2K | |
| Bromide SCHEMBL15329021 | 1.00 | CA1 (0.64) | CA1CA2KMT2AMEN1EEF2K | |
| SCHEMBL4070935 | 0.98 | CA1 (0.61) | CA1CA2KMT2AMEN1EEF2K | |
| SCHEMBL4068859 | 0.98 | CA1 (0.61) | CA1CA2KMT2AMEN1EEF2K | |
| SCHEMBL4059675 | 0.98 | CA1 (0.61) | CA1CA2KMT2AMEN1EEF2K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697465-B1 | POLYMER NANOCOMPOSITES AND METHODS FOR THEIR PREPARATION | GEN ELECTRIC (US) | 2008-02-13 | — | — | EP | disclosed |
| EP-1697465-A2 | POLYMER NANOCOMPOSITES AND METHODS FOR THEIR PREPARATION | GENERAL ELECTRIC COMPANY (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005061623-A2 | POLYMER NANOCOMPOSITES AND METHODS FOR THEIR PREPARATION | GENERAL ELECTRIC COMPANY (US) | 2005-07-07 | — | — | WO | disclosed |
| US-20050137310-A1 | Polymer nanocomposites and methods for their preparation | CITIBANK, N.A., AS COLLATERAL AGENT | 2005-06-23 | — | — | US | disclosed |