Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 16/20 | 0.69 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.69 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2166970 | 0.81 | HRH4 (1.00) | HRH4PIK3CBHRH3 | |
| SCHEMBL4401397 | 0.78 | HRH4 (0.91) | HRH4PIK3CBHRH3 | |
| SCHEMBL4392709 | 0.74 | HRH4 (0.66) | HRH4PIK3CBHRH3 | |
| SCHEMBL4392707 | 0.72 | HRH4 (0.64) | HRH4PIK3CBHRH3 | |
| SCHEMBL6244393 | 0.72 | HRH4 (0.60) | HRH4PIK3CBSMN1; SMN2 | |
| SCHEMBL15521620 | 0.71 | HRH4 (0.82) | HRH4HRH3 | |
| SCHEMBL15521589 | 0.71 | HRH4 (1.00) | HRH4HRH3 | |
| SCHEMBL28736253 | 0.70 | SMN1; SMN2 (0.68) | HRH4PIK3CBSMN1; SMN2 | |
| SCHEMBL1319082 | 0.70 | SMN1; SMN2 (0.68) | HRH4PIK3CBSMN1; SMN2 | |
| SCHEMBL7022867 | 0.70 | SMN1; SMN2 (0.68) | HRH4PIK3CBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928862-A1 | 2-AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR ACTIVITY | Palau Pharma, S.A. (ES) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007031529-A1 | 2-AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR ACTIVITY | PALAU PHARMA, S.A. (ES) | 2007-03-22 | — | — | WO | disclosed |