⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24619019 | 1.00 | — | — | |
| SCHEMBL20841336 | 1.00 | — | — | |
| SCHEMBL867968 | 0.81 | — | — | |
| SCHEMBL29332611 | 0.81 | — | — | |
| SCHEMBL7624170 | 0.79 | CRBN (0.32) | — | |
| SCHEMBL22175597 | 0.77 | CRBN (0.31) | — | |
| SCHEMBL25838009 | 0.77 | — | — | |
| SCHEMBL17826592 | 0.75 | — | — | |
| SCHEMBL48294 | 0.75 | — | — | |
| SCHEMBL29626444 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12565494-B2 | Inhibitors of human respiratory syncytial virus and metapneumovirus | MERCK SHARP & DOHME LLC | 2026-03-03 | — | — | US | claimed |
| US-20230365551-A1 | INHIBITORS OF HUMAN RESPIRATORY SYNCYTIAL VIRUS AND METAPNEUMOVIRUS | MERCK SHARP & DOHME LLC (US) | 2023-11-16 | — | — | US | claimed |
| EP-0509821-B1 | Substituted acetoxyazetidinone derivatives and process for preparing 4-acyloxyazetidinone derivatives | TAKASAGO PERFUMERY CO LTD (JP) | 1995-12-27 | — | — | EP | claimed |
| EP-0509821-A1 | Substituted acetoxyazetidinone derivatives and process for preparing 4-acyloxyazetidinone derivatives | Takasago International Corporation (JP) | 1992-10-21 | — | — | EP | claimed |
| CN-118019737-A | Beta-lactam derivatives for the treatment of diseases | 英矽智能科技知识产权有限公司 | 2024-05-10 | — | — | CN | disclosed |
| US-20230192667-A1 | BETA-LACTAM DERIVATIVES FOR THE TREATMENT OF DISEASES | INSILICO MEDICINE IP LIMITED (HK) | 2023-06-22 | — | — | US | disclosed |
| US-9771321-B2 | Small molecules that covalently modify transthyretin | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-09-26 | — | — | US | disclosed |
| US-20170190660-A9 | Small Molecules That Covalently Modify Transthyretin | KELLY JEFFERY W (US) | 2017-07-06 | — | — | US | disclosed |
| US-20160257706-A1 | Beta-D-2'-DEOXY-2'-alpha-FLUORO-2'-beta-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR HCV TREATMENT | Atea Pharmaceuticals, Inc. (US) | 2016-09-08 | — | — | US | disclosed |
| US-20160152674-A1 | TDF-RELATED COMPOUNDS AND ANALOGS THEREOF | THRASOS INNOVATION, INC. (CA) | 2016-06-02 | — | — | US | disclosed |
| EP-2343069-B1 | Heterocyclic aspartyl protease inhibitors | MERCK SHARP & DOHME (US) | 2016-03-02 | — | — | EP | disclosed |
| US-9181301-B2 | TDF-related compounds and analogs thereof | THRASOS INNOVATION, INC. (CA) | 2015-11-10 | — | — | US | disclosed |
| US-5288862-A | Reacting azetidinone or derivative with carboxylic acid in presence of ruthenium compound, aldehyde, oxygen | TAKASAGO INTERNATIONAL CORPORATION (JP) | 1994-02-22 | — | — | US | disclosed |
| US-5204460-A | Reacting azetidinone compound with acetic acid and oxidizing agent in the presence of ruthenium catalyst | TAKASAGO INTERNATIONAL CORPORATION (JP) | 1993-04-20 | — | — | US | disclosed |
| US-5191076-A | Penicillin intermediates | TAKASAGO INTERNATIONAL CORPORATION (JP) | 1993-03-02 | — | — | US | disclosed |
| EP-0509821-A1 | Substituted acetoxyazetidinone derivatives and process for preparing 4-acyloxyazetidinone derivatives | Takasago International Corporation (JP) | 1992-10-21 | — | — | EP | disclosed |
| EP-0488611-A1 | Process for producing 4-acetoxyazetidinones | Takasago International Corporation (JP) | 1992-06-03 | — | — | EP | disclosed |
| US-5081239-A | Reacting an azetidinone with acetic acid and an oxidizer | TAKASAGO INTERNATIONAL CORPORATION (JP) | 1992-01-14 | — | — | US | disclosed |
| EP-0371875-A2 | Process for preparing 4-acetoxyazetidinones | Takasago International Corporation (JP) | 1990-06-06 | — | — | EP | disclosed |
| US-4683303-A | Reduction process for the preparation of 4-unsubstituted azetidin-2-ones | PFAENDLER HANS R (DE) | 1987-07-28 | — | — | US | disclosed |