Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 19/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 16/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.61 |
| ▸ | MLNR | O43193 | 1/20 | 0.61 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | HTR1A | P08908 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | DRD2 | P14416 | 1/20 | 0.61 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.61 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.61 |
| ▸ | HTR2A | P28223 | 1/20 | 0.61 |
| ▸ | HTR2C | P28335 | 1/20 | 0.61 |
| ▸ | MC4R | P32245 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21346285 | 1.00 | SLC6A4 (1.00) | SLC6A4SLC6A2SLC6A3MLNRCACNA1F | |
| Sulfuric Acid SCHEMBL4224 | 0.93 | SLC6A4 (0.87) | SLC6A4SLC6A2SLC6A3MLNRCACNA1F | |
| Oxalic Acid SCHEMBL9746 | 0.93 | SLC6A4 (0.87) | SLC6A4SLC6A2SLC6A3MLNRCACNA1F | |
| Sulfuric Acid SCHEMBL5305469 | 0.93 | SLC6A4 (0.87) | SLC6A4SLC6A2SLC6A3MLNRCACNA1F | |
| SCHEMBL21722633 | 0.84 | SLC6A4 (0.72) | SLC6A4SLC6A2SLC6A3MLNRCACNA1F | |
| SCHEMBL21731163 | 0.84 | SLC6A4 (0.72) | SLC6A4SLC6A2SLC6A3MLNRCACNA1F | |
| SCHEMBL29447514 | 0.84 | SLC6A4 (0.72) | SLC6A4SLC6A2SLC6A3MLNRCACNA1F | |
| SCHEMBL21722632 | 0.84 | SLC6A4 (0.72) | SLC6A4SLC6A2SLC6A3MLNRCACNA1F | |
| SCHEMBL29974782 | 0.84 | SLC6A4 (0.72) | SLC6A4SLC6A2SLC6A3MLNRCACNA1F | |
| SCHEMBL2722680 | 0.81 | SLC6A4 (1.00) | SLC6A4SLC6A2SLC6A3CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008133884-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | COMBINATORX, INCORPORATED (US) | 2008-11-06 | — | — | WO | disclosed |