Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 8/20 | 0.56 |
| ▸ | GSK3A | P49840 | 4/20 | 0.56 |
| ▸ | CDK1 | P06493 | 3/20 | 0.56 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.55 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.55 |
| ▸ | SLC9A5 | Q14940 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.33 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4669938 | 0.84 | GSK3B (0.66) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL14175422 | 0.82 | GSK3B (0.64) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL4671986 | 0.82 | GSK3B (0.58) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL4399102 | 0.81 | GSK3B (0.67) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL4672216 | 0.79 | GSK3B (0.55) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL5093471 | 0.78 | GSK3B (0.63) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL5099975 | 0.77 | GSK3B (0.63) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL5091527 | 0.77 | GSK3B (0.57) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL5098978 | 0.77 | GSK3B (0.63) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL4401594 | 0.76 | GSK3B (0.75) | GSK3BGSK3ACDK1CCNB2CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7384942-B2 | 3-(2,4-dichlorophenyl)-5-bromoyrazine-2-ylamine; inhibiting the formation of neurofibrillary tangles; neurodegenerative, brain disorders; treatment of Alzheimer's disease with one or more additional agents donepezil or tacrine; anticarcinogenic, antiischemic, antidiabetic; insulin resistance | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-06-10 | — | — | US | disclosed |
| US-6949547-B2 | Pyrazine based inhibitors of glycogen synthase kinase 3 | CHIRON CORPORATION (US) | 2005-09-27 | — | — | US | disclosed |