Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | KDM1A | O60341 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA7 | P43166 | 3/20 | 0.38 |
| ▸ | CA13 | Q8N1Q1 | 3/20 | 0.38 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4909225 | 0.79 | KMT2A (0.51) | KMT2ACYP1A2CYP2C9CYP2C19KDM1A | |
| SCHEMBL4898446 | 0.75 | KMT2A (0.52) | KMT2ACYP1A2CYP2C9CYP2C19KDM1A | |
| SCHEMBL2729737 | 0.74 | KMT2A (0.60) | KMT2ACYP1A2CYP2C9CYP2C19KDM1A | |
| SCHEMBL6218562 | 0.73 | KMT2A (0.76) | KMT2ACYP1A2CYP2C9CYP2C19KDM1A | |
| SCHEMBL4420483 | 0.73 | RXFP1 (0.61) | KMT2ACYP1A2CYP2C9CYP2C19KDM1A | |
| SCHEMBL4907117 | 0.73 | KDM1A (0.56) | KMT2ACYP1A2CYP2C9CYP2C19KDM1A | |
| SCHEMBL2132489 | 0.70 | KMT2A (0.60) | KMT2ACYP1A2CYP2C9CYP2C19KDM1A | |
| SCHEMBL5702570 | 0.70 | CA1 (0.50) | KMT2AALDH1A1HPGDMEN1CA1 | |
| SCHEMBL29894839 | 0.70 | CA1 (0.50) | KMT2AALDH1A1HPGDMEN1CA1 | |
| SCHEMBL1176202 | 0.69 | KMT2A (0.58) | KMT2ACYP1A2CYP2C9CYP2C19KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984377-A2 | INHIBITORS OF TNF ALPHA , PDE4 AND B-RAF, COMPOSITIONS THEREOF AND METHODS OF USE THEREWITH | Signal Pharmaceuticals LLC (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007084560-A2 | INHIBITORS OF TNFα, PDE4 AND B-RAF, COMPOSITIONS THEREOF AND METHODS OF USE THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2007-07-26 | — | — | WO | disclosed |