Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 3/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.34 |
| ▸ | PDE2A | O00408 | 4/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.31 |
| ▸ | POLRMT | O00411 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14312912 | 0.85 | SRC (0.43) | DOT1LPIK3CDRIPK1 | |
| SCHEMBL60490 | 0.84 | PDE2A (0.43) | DOT1LCSNK2A2CSNK2A1PDE2APDE3A | |
| SCHEMBL5128661 | 0.81 | CSNK2A2 (0.40) | DOT1LCSNK2A2CSNK2A1PDE2APDE3A | |
| SCHEMBL14488121 | 0.81 | PDE2A (0.50) | PDE2APDE3APDE3B | |
| SCHEMBL16011360 | 0.81 | PDE2A (0.50) | PDE2APDE3APDE3B | |
| SCHEMBL5077314 | 0.77 | PDE2A (0.44) | CSNK2A2CSNK2A1PDE2APDE3APDE3B | |
| SCHEMBL5080389 | 0.75 | CSNK2A2 (0.35) | CSNK2A2CSNK2A1PDE2APDE3APIK3CD | |
| SCHEMBL28911462 | 0.75 | DOT1L (0.39) | DOT1LCSNK2A2CSNK2A1PDE2APDE3A | |
| SCHEMBL19377763 | 0.73 | TYRO3 (0.45) | CSNK2A2CSNK2A1PDE2APDE3APIK3CD | |
| SCHEMBL31391115 | 0.69 | MAP4K4 (0.43) | DOT1LPIK3CDPOLRMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945222-A2 | PYRROLO[2,1-F] [1,2,4] TRIAZIN-4-YLAMINES IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | Bayer HealthCare AG (DE) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007056170-A2 | PYRROLO[2,1-F] [1,2,4] TRIAZIN-4-YLAMINES IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | BAYER HEALTHCARE AG (DE) | 2007-05-18 | — | — | WO | disclosed |