Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | GAPDH | P04406 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | RNASE1 | P07998 | 1/20 | 0.44 |
| ▸ | P2RY6 | Q15077 | 2/20 | 0.43 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.43 |
| ▸ | NT5E | P21589 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | HBB | P68871 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9002102 | 1.00 | MEN1 (0.61) | MEN1USP2POLBKMT2AGAPDH | |
| SCHEMBL9002093 | 1.00 | MEN1 (0.61) | MEN1USP2POLBKMT2AGAPDH | |
| SCHEMBL20983914 | 1.00 | MEN1 (0.61) | MEN1USP2POLBKMT2AGAPDH | |
| SCHEMBL7942376 | 1.00 | MEN1 (0.61) | MEN1USP2POLBKMT2AGAPDH | |
| SCHEMBL5717456 | 0.95 | MEN1 (0.59) | MEN1USP2POLBKMT2AGAPDH | |
| SCHEMBL5717451 | 0.95 | MEN1 (0.59) | MEN1USP2POLBKMT2AGAPDH | |
| SCHEMBL9137347 | 0.94 | MEN1 (0.55) | MEN1USP2POLBKMT2AGAPDH | |
| SCHEMBL25399138 | 0.92 | MEN1 (0.55) | MEN1USP2POLBKMT2AGAPDH | |
| SCHEMBL5717506 | 0.92 | MEN1 (0.55) | MEN1USP2POLBKMT2AGAPDH | |
| SCHEMBL5717501 | 0.92 | MEN1 (0.55) | MEN1USP2POLBKMT2AGAPDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080050425-A1 | Combination Chemotherapy Comprising 5-Fluorouracil or a Derivative Thereof and a Liposomal Platinum Complex | ANTIGENICS, INC. | 2008-02-28 | — | — | US | disclosed |
| EP-1631301-A4 | COMBINATION CHEMOTHERAPY COMPRISING 5-FLUOROURACIL OR A DERIVATIVE THEREOF AND A LIPOSOMAL PLATINUM COMPLEX | ARONEX PHARMACEUTICALS INC (US) | 2006-06-07 | — | — | EP | disclosed |
| EP-1631301-A1 | COMBINATION CHEMOTHERAPY COMPRISING 5-FLUOROURACIL OR A DERIVATIVE THEREOF AND A LIPOSOMAL PLATINUM COMPLEX | Aronex Pharmaceuticals Inc. (US) | 2006-03-08 | — | — | EP | disclosed |
| WO-2004103382-A1 | COMBINATION CHEMOTHERAPY COMPRISING 5-FLUOROURACIL OR A DERIVATIVE THEREOF AND A LIPOSOMAL PLATINUM COMPLEX | ARONEX PHARMACEUTICALS, INC. (US) | 2004-12-02 | — | — | WO | disclosed |
| US-4122251-A | Process for production of 5-fluorouracil and its derivatives | DAIKIN KOGYO CO., LTD. (JP) | 1978-10-24 | — | — | US | disclosed |