Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 10/20 | 0.45 |
| ▸ | ABL1 | P00519 | 6/20 | 0.45 |
| ▸ | RET | P07949 | 5/20 | 0.45 |
| ▸ | KDR | P35968 | 4/20 | 0.45 |
| ▸ | KIF5B | P33176 | 3/20 | 0.45 |
| ▸ | SRC | P12931 | 3/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | INSR | P06213 | 2/20 | 0.45 |
| ▸ | LCK | P06239 | 2/20 | 0.45 |
| ▸ | KIT | P10721 | 2/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.45 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | NPM1 | P06748 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | LYN | P07948 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL398750 | 0.88 | IGF1R (0.41) | IGF1RABL1RETKDRKIF5B | |
| SCHEMBL400988 | 0.86 | ABL1 (0.47) | IGF1RABL1RETKDRKIF5B | |
| SCHEMBL5084883 | 0.86 | IGF1R (0.53) | IGF1RABL1RETKDRKIF5B | |
| SCHEMBL402134 | 0.84 | LCK (0.47) | IGF1RABL1RETKDRSRC | |
| SCHEMBL401858 | 0.84 | ABL1 (0.41) | IGF1RABL1RETKDRKIF5B | |
| SCHEMBL399379 | 0.83 | IGF1R (0.40) | IGF1RABL1RETKDRKIF5B | |
| SCHEMBL401866 | 0.75 | IGF1R (0.49) | IGF1RABL1RETKDRKIF5B | |
| SCHEMBL13314417 | 0.75 | ABL1 (0.56) | IGF1RABL1RETKDRKIF5B | |
| SCHEMBL401204 | 0.74 | IGF1R (0.55) | IGF1RABL1RETKDRSRC | |
| SCHEMBL401058 | 0.73 | IGF1R (0.53) | IGF1RABL1RETKDRKIF5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979002-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI Pharmaceuticals, Inc. (US) | 2008-10-15 | — | — | EP | claimed |
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | claimed |
| WO-2007075554-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2007-07-05 | — | — | WO | claimed |