Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 20/20 | 0.83 |
| ▸ | HDAC8 | Q9BY41 | 16/20 | 0.83 |
| ▸ | HDAC2 | Q92769 | 15/20 | 0.83 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5075672 | 0.92 | HDAC6 (0.76) | HDAC6HDAC8HDAC2HDAC1HDAC3 | |
| SCHEMBL5075670 | 0.92 | HDAC6 (0.76) | HDAC6HDAC8HDAC2HDAC1HDAC3 | |
| SCHEMBL5078399 | 0.91 | HDAC6 (1.00) | HDAC6HDAC8HDAC2HDAC1 | |
| SCHEMBL5078396 | 0.91 | HDAC6 (1.00) | HDAC6HDAC8HDAC2HDAC1 | |
| SCHEMBL5082166 | 0.91 | HDAC6 (1.00) | HDAC6HDAC8HDAC2HDAC1 | |
| SCHEMBL5579314 | 0.90 | HDAC6 (0.86) | HDAC6HDAC8HDAC2HDAC1 | |
| SCHEMBL5078349 | 0.90 | HDAC6 (0.86) | HDAC6HDAC8HDAC2HDAC1 | |
| SCHEMBL5078389 | 0.89 | HDAC6 (1.00) | HDAC6HDAC8HDAC2HDAC1 | |
| SCHEMBL5078392 | 0.89 | HDAC6 (1.00) | HDAC6HDAC8HDAC2HDAC1 | |
| SCHEMBL5077642 | 0.85 | HDAC6 (1.00) | HDAC6HDAC8HDAC2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101296910-A | Benzodiazepine and benzopiperazine analog inhibitors of histone deacetylase | METHYLGENE INC (CA) | 2008-10-29 | — | — | CN | claimed |
| EP-1940805-A1 | BENZODIAZEPINE AND BENZOPIPERAZINE ANALOG INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2008-07-09 | — | — | EP | claimed |
| WO-2007022638-A1 | BENZODIAZEPINE AND BENZOPIPERAZINE ANALOG INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2007-03-01 | — | — | WO | claimed |
| CN-101296910-A | Benzodiazepine and benzopiperazine analog inhibitors of histone deacetylase | METHYLGENE INC (CA) | 2008-10-29 | — | — | CN | disclosed |