Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 13/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | VEGFA | P15692 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | PDE5A | O76074 | 1/20 | 0.50 |
| ▸ | TNF | P01375 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PDE1A | P54750 | 1/20 | 0.50 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Atizoram SCHEMBL14418236 | 1.00 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| Atizoram SCHEMBL7270902 | 1.00 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| Atizoram SCHEMBL450389 | 1.00 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| Atizoram SCHEMBL13016486 | 1.00 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| Atizoram SCHEMBL14473158 | 1.00 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| Atizoram SCHEMBL5963836 | 1.00 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| Atizoram SCHEMBL450388 | 1.00 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| Atizoram SCHEMBL7270904 | 1.00 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| Atizoram SCHEMBL20883039 | 1.00 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| Atizoram SCHEMBL3416683 | 1.00 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8242146-B2 | Administering ROFLUMILAS and DICLOFENAC; antiinflammatory agents | NYCOMED GMBH (DE) | 2012-08-14 | — | — | US | disclosed |
| US-20080255209-A1 | Combination of a NSAID and a PDE-4 inhibitor | NYCOMED GMBH (DE) | 2008-10-16 | — | — | US | disclosed |