Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 11/20 | 0.39 |
| ▸ | INSR | P06213 | 5/20 | 0.39 |
| ▸ | KDR | P35968 | 4/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 7/20 | 0.37 |
| ▸ | LCK | P06239 | 4/20 | 0.37 |
| ▸ | LYN | P07948 | 4/20 | 0.37 |
| ▸ | FLT3 | P36888 | 4/20 | 0.37 |
| ▸ | KIT | P10721 | 3/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.37 |
| ▸ | FLT1 | P17948 | 3/20 | 0.37 |
| ▸ | FLT4 | P35916 | 3/20 | 0.37 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.37 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 2/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5138051 | 0.88 | IGF1R (0.35) | IGF1RINSRKDREGFRBTK | |
| SCHEMBL5142261 | 0.86 | IGF1R (0.38) | IGF1RINSRKDREGFRCYP3A4 | |
| SCHEMBL396331 | 0.86 | BTK (0.54) | IGF1RINSRKDREGFRBTK | |
| SCHEMBL5138247 | 0.79 | IGF1R (0.42) | IGF1RINSRKDREGFRCYP3A4 | |
| SCHEMBL5138853 | 0.77 | IGF1R (0.43) | IGF1RINSRKDREGFRBTK | |
| SCHEMBL400678 | 0.76 | BTK (0.50) | IGF1RINSRKDREGFRBTK | |
| SCHEMBL402558 | 0.76 | BTK (0.46) | IGF1RINSRKDREGFRBTK | |
| SCHEMBL400064 | 0.75 | IGF1R (0.68) | IGF1RINSRKDREGFRBTK | |
| SCHEMBL5138129 | 0.74 | IGF1R (0.46) | IGF1RINSRKDREGFRBTK | |
| SCHEMBL5085578 | 0.73 | IGF1R (0.55) | IGF1RINSRKDREGFRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979002-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI Pharmaceuticals, Inc. (US) | 2008-10-15 | — | — | EP | disclosed |
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |
| WO-2007075554-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |