Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 5/20 | 0.67 |
| ▸ | EGFR | P00533 | 10/20 | 0.61 |
| ▸ | KDR | P35968 | 7/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.52 |
| ▸ | FLT1 | P17948 | 3/20 | 0.52 |
| ▸ | FLT4 | P35916 | 3/20 | 0.52 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.51 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5022513 | 0.90 | AURKA (0.72) | AURKAEGFRKDRFGFR1FLT1 | |
| SCHEMBL5022398 | 0.87 | AURKA (0.70) | AURKAEGFRKDRFGFR1FLT1 | |
| SCHEMBL5091126 | 0.86 | AURKA (0.68) | AURKAEGFRKDRFLT4EPHB4 | |
| Trifluoroacetic Acid SCHEMBL5025451 | 0.85 | AURKA (0.62) | AURKAEGFRKDRFGFR1FLT1 | |
| SCHEMBL5091131 | 0.85 | AURKA (0.69) | AURKAEGFRKDRFLT4EPHB4 | |
| SCHEMBL5022873 | 0.84 | AURKA (0.67) | AURKAEGFRKDRFLT4EPHB4 | |
| SCHEMBL5022967 | 0.83 | AURKA (0.65) | AURKAEGFRKDRAURKB | |
| SCHEMBL5016588 | 0.82 | AURKA (0.65) | AURKAEGFRKDRFLT4EPHB4 | |
| SCHEMBL5016618 | 0.81 | AURKA (0.69) | AURKAEGFRKDRFLT4EPHB4 | |
| SCHEMBL5026765 | 0.81 | AURKA (0.64) | AURKAEGFRKDRFLT4EPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575966-B1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-10-29 | — | — | EP | claimed |