Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 8/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.48 |
| ▸ | INSR | P06213 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 10/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | LYN | P07948 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | FRK | P42685 | 1/20 | 0.35 |
| ▸ | STK3 | Q13188 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.35 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5083358 | 0.91 | IGF1R (0.58) | IGF1RCYP3A4INSREGFRKDR | |
| SCHEMBL5078929 | 0.83 | IGF1R (0.35) | IGF1RCYP3A4INSREGFRKDR | |
| SCHEMBL5086596 | 0.77 | TNK2 (0.42) | IGF1RCYP3A4INSREGFRKDR | |
| SCHEMBL5081269 | 0.77 | CYP3A4 (0.39) | IGF1RCYP3A4SYKTNK2 | |
| SCHEMBL5086159 | 0.76 | TNK2 (0.35) | IGF1RCYP3A4SYKTNK2 | |
| SCHEMBL5085066 | 0.76 | IGF1R (0.44) | IGF1RCYP3A4INSREGFRKDR | |
| SCHEMBL4070971 | 0.74 | IGF1R (0.45) | IGF1RCYP3A4INSREGFRKDR | |
| SCHEMBL401092 | 0.74 | IGF1R (0.85) | IGF1RCYP3A4INSREGFRKDR | |
| SCHEMBL5076858 | 0.74 | IGF1R (0.58) | IGF1RCYP3A4INSRTNK2 | |
| SCHEMBL5076854 | 0.74 | IGF1R (0.58) | IGF1RCYP3A4INSRTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |