Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 12/20 | 0.64 |
| ▸ | MMP1 | P03956 | 1/20 | 0.64 |
| ▸ | MMP2 | P08253 | 1/20 | 0.64 |
| ▸ | MMP7 | P09237 | 1/20 | 0.64 |
| ▸ | MMP10 | P09238 | 1/20 | 0.64 |
| ▸ | MMP9 | P14780 | 1/20 | 0.64 |
| ▸ | MMP13 | P45452 | 1/20 | 0.64 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.64 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.64 |
| ▸ | MMP14 | P50281 | 1/20 | 0.64 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.64 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.64 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.64 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.64 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.64 |
| ▸ | NPY1R | P25929 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 3/20 | 0.48 |
| ▸ | MME | P08473 | 1/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | CCR8 | P51685 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5888987 | 0.91 | APP (0.68) | APPMMP1MMP2MMP7MMP10 | |
| SCHEMBL5888886 | 0.89 | APP (0.59) | APPMMP1MMP2MMP7MMP10 | |
| SCHEMBL4486572 | 0.86 | APP (0.72) | APPMMP1MMP2MMP7MMP10 | |
| SCHEMBL4500891 | 0.86 | APP (0.72) | APPMMP1MMP2MMP7MMP10 | |
| SCHEMBL4494890 | 0.86 | APP (0.59) | APPMMP1MMP2MMP7MMP10 | |
| SCHEMBL4499722 | 0.86 | APP (0.71) | APPMMP1MMP2MMP7MMP10 | |
| SCHEMBL4479583 | 0.86 | APP (0.59) | APPMMP1MMP2MMP7MMP10 | |
| SCHEMBL4484575 | 0.85 | APP (0.67) | APPMMP1MMP2MMP7MMP10 | |
| SCHEMBL4498777 | 0.85 | APP (0.58) | APPMMP1MMP2MMP7MMP10 | |
| SCHEMBL4478799 | 0.85 | APP (0.67) | APPMMP1MMP2MMP7MMP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423033-B2 | Hydroxyalkanoylaminolactams and related structures as inhibitors of aβ protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2008-09-09 | — | — | US | disclosed |
| US-20080132482-A1 | HYDROXYALKANOYLAMINOLACTAMS AND RELATED STRUCTURES AS INHIBITORS OF A BETA PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2008-06-05 | — | — | US | disclosed |
| US-7112583-B2 | Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2006-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132482-A1 | HYDROXYALKANOYLAMINOLACTAMS AND RELATED STRUCTURES AS INHIBITORS OF A BETA PROTEIN PRODUCTION | APP, BACE1, APH1A | APP 1/4885MMP1 2449/4885MMP2 1351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.