⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29854 | 0.95 | — | — | |
| SCHEMBL27992786 | 0.90 | — | — | |
| SCHEMBL28636235 | 0.90 | — | — | |
| Bromide SCHEMBL6059439 | 0.90 | — | — | |
| SCHEMBL6060982 | 0.90 | — | — | |
| SCHEMBL30539229 | 0.90 | — | — | |
| SCHEMBL28459377 | 0.90 | — | — | |
| Methane SCHEMBL19511813 | 0.90 | — | — | |
| Ethane SCHEMBL19511829 | 0.90 | — | — | |
| Lithium SCHEMBL3206041 | 0.90 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008015714-A2 | PROCESS FOR THE PREPARATION OF 1,1-DICHLORO-2-ALKYLETHYLENE | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2008-02-07 | — | — | WO | claimed |
| US-5817875-A | Methods for the manufacture of terbinafine | KARIMIAN KHASHAYAR (CA) | 1998-10-06 | — | — | US | claimed |
| CN-112219258-B | Spin-on metallization | 弗萨姆材料美国有限责任公司 | 2024-12-31 | — | — | CN | disclosed |
| CN-108017679-A | Disubstituted alkynes hexacarbonyl dicobalt compounds, methods of making and methods of use thereof | 弗萨姆材料美国有限责任公司 | 2018-05-11 | — | — | CN | disclosed |
| CN-102898314-B | Preparation method of terbinafine hydrochloride | SHANDONG BOYUAN PHARMACEUTICAL CO LTD | 2014-09-03 | — | — | CN | disclosed |
| CN-102898314-A | Preparation method of terbinafine hydrochloride | SHANDONG BOYUAN PHARMACEUTICAL CO LTD | 2013-01-30 | — | — | CN | disclosed |
| WO-2008015714-A2 | PROCESS FOR THE PREPARATION OF 1,1-DICHLORO-2-ALKYLETHYLENE | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2008-02-07 | — | — | WO | disclosed |
| EP-1236709-B1 | A process for the preparation of terbinafine | DIPHARMA FRANCIS SRL (IT) | 2007-12-05 | — | — | EP | disclosed |
| WO-2005058794-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF TERBINAFINE INTERMEDIATE | NATCO PHARMA LIMITED (IN) | 2005-06-30 | — | — | WO | disclosed |
| US-6515181-B2 | Reacting tert-butylacetylene with (3-chloro-2-propenyl)-n-methyl-1-naphthalene methanamine in the presence of copper (I) salts and of a base, in the absence of palladium | DIPHARMA S.P.A. (IT) | 2003-02-04 | — | — | US | disclosed |
| US-20020123651-A1 | Process for the preparation of terbinafine | DIPHARMA S.P.A. (IT) | 2002-09-05 | — | — | US | disclosed |
| EP-1236709-A2 | A process for the preparation of terbinafine | Dinamite Dipharma S.p.A. (in abbreviated form Dipharma S.p.A.) (IT) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001077064-A1 | METHOD FOR THE PREPARATION OF (E)-N-(6,6-DIMETHYL-2-HEPTEN-4-YNYL)-N-METHYL-1-NAPHTHALENEMETHANAMINE (TERBINAFINE) | SLOVAKOFARMA A.S. (SK) | 2001-10-18 | — | — | WO | disclosed |
| US-5817875-A | Methods for the manufacture of terbinafine | KARIMIAN KHASHAYAR (CA) | 1998-10-06 | — | — | US | disclosed |
| US-4868337-A | Optically active borinic esters and ketones | ALDRICH-BORANES, INC. (US) | 1989-09-19 | — | — | US | disclosed |
| US-4795821-A | Optically active borinic esters and ketones | ALDRICH-BORANES, INC. (US) | 1989-01-03 | — | — | US | disclosed |