Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 2/20 | 0.36 |
| ▸ | MMP2 | P08253 | 4/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | MMP3 | P08254 | 2/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL5085160 | 1.00 | HTR2A (0.41) | HTR2AMEN1KMT2ACSNK1EATM | |
| Hydrochloric Acid SCHEMBL5086793 | 0.97 | MEN1 (0.43) | HTR2AMEN1KMT2ACSNK1EATM | |
| Hydrochloric Acid SCHEMBL5085137 | 0.97 | MEN1 (0.43) | HTR2AMEN1KMT2ACSNK1EATM | |
| Iodide SCHEMBL5092387 | 0.97 | HTR2A (0.41) | HTR2AMEN1KMT2ACSNK1EATM | |
| Iodide SCHEMBL5092417 | 0.97 | HTR2A (0.41) | HTR2AMEN1KMT2ACSNK1EATM | |
| Hydrochloric Acid SCHEMBL11129264 | 0.83 | HTR2A (0.42) | HTR2AMEN1KMT2ACSNK1EATM | |
| Hydrochloric Acid SCHEMBL11128801 | 0.83 | HTR2A (0.42) | HTR2AMEN1KMT2ACSNK1EATM | |
| Hydrochloric Acid SCHEMBL11126410 | 0.83 | HTR2A (0.42) | HTR2AMEN1KMT2ACSNK1EATM | |
| Hydrochloric Acid SCHEMBL11124491 | 0.83 | HTR2A (0.42) | HTR2AMEN1KMT2ACSNK1EATM | |
| Water SCHEMBL11431557 | 0.83 | HTR2A (0.42) | HTR2AMEN1KMT2ACSNK1ESLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214386-A1 | Stability; easily separated from solution; surface treatment of catalyst with Group seven compound; reacting epoxide with carbon dioxide | NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) | 2008-09-04 | — | — | US | disclosed |