Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Dimetamfetamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.64 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.64 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.64 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.64 |
| ▸ | HTR2A | P28223 | 1/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.64 |
| ▸ | MAOB | P27338 | 6/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.60 |
| ▸ | MAOA | P21397 | 5/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.56 |
| ▸ | SNCA | P37840 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimetamfetamine SCHEMBL12203605 | 0.98 | SLC6A4 (0.67) | SLC6A4SLC6A2ADRA2BADRA2CADRA1A | |
| Dimetamfetamine SCHEMBL727641 | 0.98 | SLC6A4 (0.67) | SLC6A4SLC6A2ADRA2BADRA2CADRA1A | |
| Dimetamfetamine SCHEMBL2110135 | 0.98 | SLC6A4 (0.67) | SLC6A4SLC6A2ADRA2BADRA2CADRA1A | |
| Dimetamfetamine SCHEMBL5091346 | 0.95 | SLC6A4 (0.64) | SLC6A4SLC6A2ADRA2BADRA2CADRA1A | |
| Dimetamfetamine SCHEMBL28689942 | 0.95 | SLC6A4 (0.64) | SLC6A4SLC6A2ADRA2BADRA2CADRA1A | |
| Dimetamfetamine SCHEMBL11773332 | 0.95 | SLC6A4 (0.64) | SLC6A4SLC6A2ADRA2BADRA2CADRA1A | |
| Dimetamfetamine SCHEMBL30559567 | 0.95 | SLC6A4 (0.64) | SLC6A4SLC6A2ADRA2BADRA2CADRA1A | |
| Dimetamfetamine SCHEMBL5091391 | 0.95 | SLC6A4 (0.64) | SLC6A4SLC6A2ADRA2BADRA2CADRA1A | |
| SCHEMBL19285766 | 0.88 | MAOB (0.69) | SLC6A4SLC6A2ADRA2BADRA2CADRA1A | |
| Dimetamfetamine SCHEMBL1240177 | 0.85 | SLC6A4 (0.53) | SLC6A4SLC6A2ADRA2BADRA2CADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214386-A1 | Stability; easily separated from solution; surface treatment of catalyst with Group seven compound; reacting epoxide with carbon dioxide | NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) | 2008-09-04 | — | — | US | disclosed |