Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 3/20 | 0.59 |
| ▸ | CDK2 | P24941 | 3/20 | 0.59 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3041819 | 0.84 | CDK2 (0.46) | CCNA2CDK2CCNA1NPC1RAB9A | |
| SCHEMBL13221083 | 0.80 | GSK3B (0.53) | CDK2ITKAURKAAURKBSYK | |
| SCHEMBL13221268 | 0.78 | CCNA2 (0.39) | CCNA2CDK2CCNA1NPC1RAB9A | |
| SCHEMBL13220975 | 0.78 | AURKA (0.54) | AURKAAURKBSYK | |
| SCHEMBL13221167 | 0.78 | IGF1R (0.44) | ITKAURKAAURKBJAK2 | |
| SCHEMBL3047500 | 0.78 | RET (0.49) | ITKAURKAAURKBSYKJAK2 | |
| SCHEMBL13221178 | 0.78 | CYP2D6 (0.44) | ITKAURKAAURKBJAK2 | |
| SCHEMBL13221176 | 0.78 | CYP2D6 (0.44) | ITKAURKAAURKBJAK2 | |
| SCHEMBL3040578 | 0.77 | MAP4K2 (0.46) | CDK2NPC1RAB9ASMN1; SMN2ATM | |
| SCHEMBL13221173 | 0.77 | IGF1R (0.43) | ITKAURKAAURKBJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2008516973-A | — | — | 2008-05-22 | — | — | JP | claimed |
| EP-1812439-A2 | KINASE INHIBITORS | Takeda San Diego, Inc. (US) | 2007-08-01 | — | — | EP | claimed |
| WO-2006044687-A2 | KINASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-04-27 | — | — | WO | claimed |