Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 12/20 | 0.43 |
| ▸ | RAF1 | P04049 | 11/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 7/20 | 0.40 |
| ▸ | LCK | P06239 | 2/20 | 0.40 |
| ▸ | FYN | P06241 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | LYN | P07948 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | ROS1 | P08922 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5089023 | 0.80 | BRAF (0.46) | BRAFRAF1MAPK14KDRLCK | |
| SCHEMBL618035 | 0.80 | RAF1 (0.57) | BRAFRAF1MAPK14KDRLCK | |
| SCHEMBL5089015 | 0.78 | BRAF (0.46) | BRAFRAF1MAPK14KDRLCK | |
| SCHEMBL177543 | 0.77 | KDR (0.60) | BRAFRAF1MAPK14KDRLCK | |
| SCHEMBL2705545 | 0.74 | RAF1 (0.62) | BRAFRAF1MAPK14KDRLCK | |
| SCHEMBL26545831 | 0.73 | BRAF (0.66) | BRAFRAF1MAPK14KDRLCK | |
| SCHEMBL14527398 | 0.69 | BRAF (0.60) | BRAFRAF1MAPK14KDRLCK | |
| SCHEMBL2329688 | 0.68 | BRAF (0.52) | BRAFRAF1KDREPHX2 | |
| SCHEMBL7971280 | 0.68 | BRAF (0.41) | BRAFRAF1 | |
| SCHEMBL5137329 | 0.68 | RAF1 (0.67) | BRAFRAF1MAPK14KDRLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7351834-B1 | ω-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors | BAYER PHARMACEUTICALS CORPORATION (US) | 2008-04-01 | — | — | US | disclosed |