Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.42 |
| ▸ | FLT1 | P17948 | 2/20 | 0.42 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.38 |
| ▸ | CDK8 | P49336 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4504479 | 0.92 | MAPK14 (0.48) | MAPK14MAPK11FLT1MINK1MAPK13 | |
| SCHEMBL4505564 | 0.91 | MAPK14 (0.47) | MAPK14MAPK11FLT1MINK1MAPK13 | |
| SCHEMBL4516836 | 0.91 | MAPK14 (0.48) | MAPK14MAPK11FLT1MINK1MAPK13 | |
| SCHEMBL4518706 | 0.90 | MAPK14 (0.46) | MAPK14MAPK11FLT1MINK1MAPK13 | |
| SCHEMBL4520265 | 0.90 | MAPK14 (0.47) | MAPK14MAPK11FLT1MINK1MAPK13 | |
| SCHEMBL4520194 | 0.90 | MAPK14 (0.46) | MAPK14MAPK11FLT1MINK1MAPK13 | |
| SCHEMBL4506651 | 0.89 | MAPK14 (0.49) | MAPK14MAPK11FLT1MINK1MAPK13 | |
| SCHEMBL5068195 | 0.89 | MAPK14 (0.48) | MAPK14MAPK11FLT1MINK1MAPK13 | |
| SCHEMBL4516122 | 0.89 | MAPK14 (0.49) | MAPK14MAPK11FLT1MINK1MAPK13 | |
| SCHEMBL4504482 | 0.89 | MAPK14 (0.46) | MAPK14MAPK11FLT1MINK1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1987022-A1 | PYRIDINONE PYRAZOLE UREA AND PYRIMIDINONE PYRAZOLE UREA DERIVATIVES | Pfizer Products Inc. (US) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007091176-A1 | PYRIDINONE PYRAZOLE UREA AND PYRIMIDINONE PYRAZOLE UREA DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2007-08-16 | — | — | WO | disclosed |