Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL118552 | 0.99 | SIRT2 (0.49) | SIRT2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL29544944 | 0.99 | SIRT2 (0.49) | SIRT2HDAC3HDAC4HDAC1HDAC7 | |
| Fluoride Ion SCHEMBL4594160 | 0.97 | SIRT2 (0.48) | SIRT2HDAC3HDAC4HDAC1HDAC7 | |
| Bromide SCHEMBL5514450 | 0.97 | SIRT2 (0.48) | SIRT2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL15769691 | 0.97 | SIRT2 (0.48) | SIRT2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL30056078 | 0.97 | SIRT2 (0.48) | SIRT2HDAC3HDAC4HDAC1HDAC7 | |
| Fluoride SCHEMBL28343187 | 0.96 | SIRT2 (0.47) | SIRT2HDAC3HDAC4HDAC1HDAC7 | |
| Fluoride Ion SCHEMBL15769690 | 0.96 | SIRT2 (0.47) | SIRT2HDAC3HDAC4HDAC1HDAC7 | |
| Fluoride SCHEMBL15769692 | 0.94 | SIRT2 (0.46) | SIRT2HDAC3HDAC4HDAC1HDAC7 | |
| Alcohol SCHEMBL23850152 | 0.93 | SIRT2 (0.45) | SIRT2HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329760-B2 | CC-1065 analog synthesis | IMMUNOGEN INC. (US) | 2008-02-12 | — | — | US | disclosed |
| EP-1492766-B1 | IMPROVED CC-1065 ANALOG SYNTHESIS | IMMUNOGEN INC (US) | 2007-05-02 | — | — | EP | disclosed |
| EP-1492766-A4 | IMPROVED CC-1065 ANALOG SYNTHESIS | IMMUNOGEN INC (US) | 2005-12-14 | — | — | EP | disclosed |
| EP-1492766-A1 | IMPROVED CC-1065 ANALOG SYNTHESIS | Immunogen, Inc. (US) | 2005-01-05 | — | — | EP | disclosed |
| WO-2003087055-A1 | IMPROVED CC-1065 ANALOG SYNTHESIS | IMMUNOGEN, INC. (US) | 2003-10-23 | — | — | WO | disclosed |
| US-20030195365-A1 | CC-1065 analog synthesis | IMMUNOGEN INC. | 2003-10-16 | — | — | US | disclosed |
| US-6534660-B1 | Halogenation, alkylation and ring-closure of protected 2-amino-4-hydroxynaphthalene under suitable conditions to provide desired racemate, isolating (-) isomer, removing protecting groups | IMMUNOGEN, INC. | 2003-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030195365-A1 | CC-1065 analog synthesis | DCUN1D5, DCUN1D1, DBN1 | SIRT2 1295/4885HDAC3 779/4885HDAC4 1592/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.