Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 8/20 | 0.68 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.49 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | PRKCG | P05129 | 1/20 | 0.37 |
| ▸ | PRKCB | P05771 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | PRKACG | P22612 | 1/20 | 0.37 |
| ▸ | PRKACB | P22694 | 1/20 | 0.37 |
| ▸ | PRKCH | P24723 | 1/20 | 0.37 |
| ▸ | PRKCI | P41743 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30556253 | 0.84 | RPS6KA5 (0.67) | RPS6KA5MKNK1MKNK2RPS6KA4BIRC5 | |
| SCHEMBL19100350 | 0.84 | RPS6KA5 (0.67) | RPS6KA5MKNK1MKNK2RPS6KA4BIRC5 | |
| SCHEMBL30886751 | 0.82 | RPS6KA5 (0.52) | RPS6KA5MKNK1MKNK2MAPTRPS6KA4 | |
| SCHEMBL18586078 | 0.82 | RPS6KA5 (0.68) | RPS6KA5MKNK1MKNK2MAPTRPS6KA4 | |
| SCHEMBL28617905 | 0.81 | RPS6KA5 (0.47) | RPS6KA5MKNK1MKNK2MAPTRPS6KA4 | |
| SCHEMBL29651176 | 0.81 | RPS6KA5 (0.47) | RPS6KA5MKNK1MKNK2MAPTRPS6KA4 | |
| SCHEMBL28612234 | 0.78 | RPS6KA5 (0.46) | RPS6KA5MKNK1MKNK2RPS6KA4BIRC5 | |
| SCHEMBL20357808 | 0.78 | RPS6KA5 (0.47) | RPS6KA5MKNK1MKNK2MAPTRPS6KA4 | |
| SCHEMBL20357868 | 0.78 | RPS6KA5 (0.47) | RPS6KA5MKNK1MKNK2MAPTRPS6KA4 | |
| SCHEMBL18585457 | 0.78 | RPS6KA5 (0.47) | RPS6KA5MKNK1MKNK2MAPTRPS6KA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399462-B2 | 4-[4-(4-benzyloxy-indol-1-yl)-pyrimidin-2-ylamino]-cyclohexanol; autoimmune, inflammatory, metabolic, neurological diseases as well as cancer and pain | ROCHE PALO ALTO LLC (US) | 2013-03-19 | — | — | US | disclosed |
| US-20080146565-A1 | JNK modulators | ROCHE PALO ALTO LLC | 2008-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146565-A1 | JNK modulators | MAPKAPK2, MAPKAPK3, MAP3K10 | RPS6KA5 114/4885MKNK1 38/4885MKNK2 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.