Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 18/20 | 0.76 |
| ▸ | HTR1B | P28222 | 12/20 | 0.76 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.76 |
| ▸ | HTR1A | P08908 | 8/20 | 0.76 |
| ▸ | DRD2 | P14416 | 2/20 | 0.59 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.59 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5088629 | 0.89 | SLC6A4 (0.81) | HTR1DHTR1BSLC6A4HTR1ADRD2 | |
| SCHEMBL5088732 | 0.88 | HTR1D (0.80) | HTR1DHTR1BSLC6A4HTR1ADRD2 | |
| SCHEMBL5092202 | 0.88 | HTR1D (0.80) | HTR1DHTR1BSLC6A4HTR1ADRD2 | |
| SCHEMBL5088686 | 0.87 | HTR1D (0.78) | HTR1DHTR1BSLC6A4HTR1ADRD2 | |
| SCHEMBL6810990 | 0.86 | HTR1D (1.00) | HTR1DHTR1BSLC6A4HTR1ADRD2 | |
| SCHEMBL6811819 | 0.86 | HTR1D (0.78) | HTR1DHTR1BSLC6A4HTR1ADRD2 | |
| SCHEMBL6808349 | 0.86 | SLC6A4 (0.73) | HTR1DHTR1BSLC6A4HTR1ADRD2 | |
| SCHEMBL6811543 | 0.85 | HTR1D (1.00) | HTR1DHTR1BSLC6A4HTR1ADRD2 | |
| SCHEMBL5093515 | 0.85 | HTR1D (0.75) | HTR1DHTR1BSLC6A4HTR1ADRD2 | |
| SCHEMBL6812134 | 0.85 | HTR1D (0.77) | HTR1DHTR1BSLC6A4HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7335660-B2 | Isochroman compounds for treatment of CNS disorders | ELI LILLY AND COMPANY (US) | 2008-02-26 | — | — | US | disclosed |
| CN-1312148-C | Isochroman compounds for treatment of CNS disorders | LILLY CO ELI (US) | 2007-04-25 | — | — | CN | disclosed |
| CN-1620447-A | Isochroman compounds for treatment of cns disorders | LILLY CO ELI (US) | 2005-05-25 | — | — | CN | disclosed |
| US-20050014750-A1 | Isochroman compounds for treatment of cns disorders | ELI LILLY AND COMPANY | 2005-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014750-A1 | Isochroman compounds for treatment of cns disorders | INA, CNR2, CNR1 | HTR1D 201/4885HTR1B 185/4885SLC6A4 506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.