Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 8/20 | 0.57 |
| ▸ | AURKA | O14965 | 4/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.53 |
| ▸ | JAK2 | O60674 | 3/20 | 0.53 |
| ▸ | CDK2 | P24941 | 6/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.52 |
| ▸ | JAK3 | P52333 | 3/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 4/20 | 0.50 |
| ▸ | ITK | Q08881 | 4/20 | 0.50 |
| ▸ | KDR | P35968 | 3/20 | 0.50 |
| ▸ | GSK3A | P49840 | 3/20 | 0.50 |
| ▸ | GSK3B | P49841 | 3/20 | 0.50 |
| ▸ | PLK4 | O00444 | 2/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.50 |
| ▸ | PAK4 | O96013 | 2/20 | 0.50 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4003164 | 0.87 | NTRK1 (0.58) | SYKAURKAAURKBNTRK1JAK2 | |
| SCHEMBL4007702 | 0.82 | NTRK1 (0.54) | SYKAURKAAURKBNTRK1JAK2 | |
| SCHEMBL4005181 | 0.81 | NTRK1 (0.54) | SYKAURKAAURKBNTRK1JAK2 | |
| SCHEMBL4975656 | 0.81 | NTRK1 (0.58) | SYKAURKAAURKBNTRK1JAK2 | |
| SCHEMBL4006056 | 0.81 | SYK (0.70) | SYKAURKAAURKBNTRK1JAK2 | |
| SCHEMBL2477119 | 0.81 | NTRK1 (0.57) | SYKAURKAAURKBNTRK1JAK2 | |
| SCHEMBL4007740 | 0.80 | NTRK1 (0.60) | SYKAURKAAURKBNTRK1JAK2 | |
| SCHEMBL4970415 | 0.80 | AURKA (0.55) | SYKAURKAAURKBNTRK1JAK2 | |
| SCHEMBL3998520 | 0.80 | JAK3 (0.58) | SYKAURKAAURKBNTRK1JAK2 | |
| SCHEMBL4972409 | 0.79 | NTRK1 (0.55) | SYKAURKAAURKBNTRK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904457-A2 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | Rigel Pharmaceuticals, Inc. (US) | 2008-04-02 | — | — | EP | disclosed |
| WO-2006133426-A2 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2006-12-14 | — | — | WO | disclosed |