Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD3 | O94806 | 1/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | FRK | P42685 | 1/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.55 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.55 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.55 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8475516 | 0.92 | CREBBP (0.56) | PRKD3MAP4K4FRKMAPK9CSNK1A1 | |
| SCHEMBL10801666 | 0.79 | PRKD3 (0.62) | PRKD3MAP4K4FRKMAPK9CSNK1A1 | |
| SCHEMBL5093475 | 0.79 | MAP4K4 (0.62) | PRKD3MAP4K4FRKMAPK9CSNK1A1 | |
| SCHEMBL8656772 | 0.79 | MAP4K4 (0.62) | PRKD3MAP4K4FRKMAPK9CSNK1A1 | |
| SCHEMBL14288457 | 0.77 | PRKD3 (0.60) | PRKD3MAP4K4FRKMAPK9CSNK1A1 | |
| SCHEMBL14002179 | 0.77 | PRKD3 (0.60) | PRKD3MAP4K4FRKMAPK9CSNK1A1 | |
| SCHEMBL10441819 | 0.77 | PRKD3 (0.60) | PRKD3MAP4K4FRKMAPK9CSNK1A1 | |
| SCHEMBL14288452 | 0.77 | MAP4K4 (0.86) | PRKD3MAP4K4FRKMAPK9CSNK1A1 | |
| SCHEMBL10441604 | 0.77 | MAP4K4 (0.63) | PRKD3MAP4K4FRKMAPK9CSNK1A1 | |
| SCHEMBL6844336 | 0.77 | MAPK14 (0.64) | PRKD3MAP4K4FRKMAPK9CSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7320993-B1 | Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents | ASTELLAS DEUTSCHLAND GMBH (DE) | 2008-01-22 | — | — | US | disclosed |
| EP-1042291-B1 | ARYL-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | KLINGE CO CHEM PHARM FAB (DE) | 2005-07-13 | — | — | EP | disclosed |