Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 3/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 8/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 8/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | POLQ | O75417 | 1/20 | 0.39 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.39 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6677088 | 0.83 | PDE2A (0.49) | PDE2AAKR1C3AKR1C2CYP1A2CYP2C9 | |
| SCHEMBL510121 | 0.79 | SRC (0.48) | AKR1C3AKR1C2MEN1ALDH1A1POLB | |
| SCHEMBL508559 | 0.78 | AKR1C3 (0.42) | PDE2AAKR1C3AKR1C2AKR1B10AKR1C4 | |
| SCHEMBL22519375 | 0.77 | PDE2A (0.47) | PDE2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL10911784 | 0.76 | PPARG (0.41) | PDE2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1903665 | 0.76 | AKR1C3 (0.59) | AKR1C3AKR1C2CYP1A2CYP2C9MEN1 | |
| Hydrochloric Acid SCHEMBL2763475 | 0.74 | AKR1C3 (0.58) | AKR1C3AKR1C2CYP1A2CYP2C9MEN1 | |
| SCHEMBL22279495 | 0.74 | PDE2A (0.45) | PDE2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL29472456 | 0.74 | PDE2A (0.45) | PDE2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL509825 | 0.74 | AKR1C3 (0.60) | AKR1C3AKR1C2CYP1A2AKR1B10AKR1C4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8507410-B2 | Pyridazinone compound and use thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2013-08-13 | — | — | US | disclosed |
| US-8470738-B2 | Pyridazinone compound and herbicide containing the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2013-06-25 | — | — | US | disclosed |
| US-20120028803-A1 | PYRIDAZINONE COMPOUND AND USE THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-02-02 | — | — | US | disclosed |
| EP-2188264-B1 | PYRIDAZINONE COMPOUND AND HERBICIDE CONTAINING THE SAME | SUMITOMO CHEMICAL CO (JP) | 2011-03-23 | — | — | EP | disclosed |
| US-20100216642-A1 | PYRIDAZINONE COMPOUND AND HERBICIDE CONTAINING THE SAME | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028803-A1 | PYRIDAZINONE COMPOUND AND USE THEREOF | C5, C1S, WEE1 | PDE2A 1625/4885AKR1C3 107/4885AKR1C2 534/4885 |
| US-20100216642-A1 | PYRIDAZINONE COMPOUND AND HERBICIDE CONTAINING THE SAME | WEE1, WEE2, CBR3 | PDE2A 1498/4885AKR1C3 103/4885AKR1C2 149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.