Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.49 |
| ▸ | CLK1 | P49759 | 3/20 | 0.49 |
| ▸ | AURKA | O14965 | 7/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 4/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 4/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.40 |
| ▸ | CLK2 | P49760 | 2/20 | 0.40 |
| ▸ | CLK3 | P49761 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.40 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5092772 | 1.00 | DYRK1A (0.49) | DYRK1ACLK1AURKARPS6KB1MAPK14 | |
| SCHEMBL5095257 | 0.93 | DYRK1A (0.42) | DYRK1ACLK1AURKARPS6KB1MAPK14 | |
| SCHEMBL5095254 | 0.93 | DYRK1A (0.42) | DYRK1ACLK1AURKARPS6KB1MAPK14 | |
| SCHEMBL5095265 | 0.88 | CLK1 (0.50) | DYRK1ACLK1AURKAMAPK14KDR | |
| SCHEMBL5095269 | 0.88 | CLK1 (0.50) | DYRK1ACLK1AURKAMAPK14KDR | |
| SCHEMBL5101082 | 0.86 | DYRK1A (0.54) | DYRK1ACLK1AURKAMAPK14KDR | |
| SCHEMBL5094463 | 0.86 | DYRK1A (0.54) | DYRK1ACLK1AURKAMAPK14KDR | |
| SCHEMBL4874122 | 0.84 | MKNK1 (0.38) | DYRK1ACLK1DYRK3DYRK2DYRK1B | |
| SCHEMBL4874129 | 0.84 | MKNK1 (0.38) | DYRK1ACLK1DYRK3DYRK2DYRK1B | |
| SCHEMBL5095406 | 0.84 | DYRK1A (0.50) | DYRK1ACLK1AURKAMAPK14KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7371862-B2 | Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2008-05-13 | — | — | US | claimed |
| US-20070112020-A1 | Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PHARMACIA ITALIA S.P.A. (IT) | 2007-05-17 | — | — | US | claimed |
| US-7371862-B2 | Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2008-05-13 | — | — | US | disclosed |
| US-20070112020-A1 | Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PHARMACIA ITALIA S.P.A. (IT) | 2007-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112020-A1 | Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K20, MAP3K6, MAP3K1 | DYRK1A 308/4885CLK1 430/4885AURKA 169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.