Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 8/20 | 0.78 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.78 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.78 |
| ▸ | CDK2 | P24941 | 3/20 | 0.63 |
| ▸ | JUN | P05412 | 1/20 | 0.63 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.61 |
| ▸ | MKNK1 | Q9BUB5 | 8/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.54 |
| ▸ | CDC7 | O00311 | 1/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.52 |
| ▸ | IDH1 | O75874 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5093826 | 0.88 | MAPK8 (0.79) | MAPK8MAPK9MAPK10CDK2JUN | |
| SCHEMBL3823251 | 0.88 | MAPK8 (0.79) | MAPK8MAPK9MAPK10CDK2JUN | |
| SCHEMBL5095675 | 0.88 | MAPK8 (1.00) | MAPK8MAPK9MAPK10CDK2JUN | |
| SCHEMBL5094105 | 0.88 | MAPK8 (1.00) | MAPK8MAPK9MAPK10CDK2JUN | |
| SCHEMBL14193723 | 0.82 | MAPK8 (0.63) | MAPK8MAPK9MAPK10CDK2CCNE1 | |
| SCHEMBL11938717 | 0.82 | MAPK8 (0.66) | MAPK8MAPK9MAPK10CDK2CCNE1 | |
| SCHEMBL21554287 | 0.81 | MKNK1 (0.79) | MAPK8MAPK9CDK2CCNE1MKNK1 | |
| SCHEMBL3470784 | 0.80 | MAPK8 (0.64) | MAPK8MAPK9MAPK10CDK2JUN | |
| SCHEMBL21554179 | 0.80 | MKNK1 (0.80) | MAPK8MAPK9CDK2CCNE1MKNK1 | |
| SCHEMBL14193109 | 0.80 | MAPK8 (0.62) | MAPK8MAPK9MAPK10CDK2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399462-B2 | 4-[4-(4-benzyloxy-indol-1-yl)-pyrimidin-2-ylamino]-cyclohexanol; autoimmune, inflammatory, metabolic, neurological diseases as well as cancer and pain | ROCHE PALO ALTO LLC (US) | 2013-03-19 | — | — | US | claimed |
| CN-101547917-A | Substituted pyrimidines and their use as JNK modulators | HOFFMANN LAROCHE (CH) | 2009-09-30 | — | — | CN | claimed |
| US-20080146565-A1 | JNK modulators | ROCHE PALO ALTO LLC | 2008-06-19 | — | — | US | claimed |
| US-8399462-B2 | 4-[4-(4-benzyloxy-indol-1-yl)-pyrimidin-2-ylamino]-cyclohexanol; autoimmune, inflammatory, metabolic, neurological diseases as well as cancer and pain | ROCHE PALO ALTO LLC (US) | 2013-03-19 | — | — | US | disclosed |
| US-8399462-B2 | 4-[4-(4-benzyloxy-indol-1-yl)-pyrimidin-2-ylamino]-cyclohexanol; autoimmune, inflammatory, metabolic, neurological diseases as well as cancer and pain | ROCHE PALO ALTO LLC (US) | 2013-03-19 | — | — | US | disclosed |
| US-8399462-B2 | 4-[4-(4-benzyloxy-indol-1-yl)-pyrimidin-2-ylamino]-cyclohexanol; autoimmune, inflammatory, metabolic, neurological diseases as well as cancer and pain | ROCHE PALO ALTO LLC (US) | 2013-03-19 | — | — | US | disclosed |
| WO-2008068171-A9 | SUBSTITUTED PYRIMIDINES AND THEIR USE AS JNK MODULATORS | HOFFMANN LA ROCHE (CH) | 2009-07-16 | — | — | WO | disclosed |
| US-20080146565-A1 | JNK modulators | ROCHE PALO ALTO LLC | 2008-06-19 | — | — | US | disclosed |
| US-20080146565-A1 | JNK modulators | ROCHE PALO ALTO LLC | 2008-06-19 | — | — | US | disclosed |
| US-20080146565-A1 | JNK modulators | ROCHE PALO ALTO LLC | 2008-06-19 | — | — | US | disclosed |
| WO-2008068171-A1 | SUBSTITUTED PYRIMIDINES AND THEIR USE AS JNK MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146565-A1 | JNK modulators | MAPKAPK2, MAPKAPK3, MAP3K10 | MAPK8 40/4885MAPK9 43/4885MAPK10 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.