Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | SERPINE1 | P05121 | 5/20 | 0.46 |
| ▸ | SNCA | P37840 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.40 |
| ▸ | PTP4A1 | Q93096 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL39875 | 0.86 | SERPINE1 (0.63) | CYP3A4SERPINE1ESR1KDM4E | |
| SCHEMBL254063 | 0.83 | CYP3A4 (0.59) | CYP3A4SERPINE1SNCAALDH1A1HSD17B10 | |
| SCHEMBL5088086 | 0.83 | CYP3A4 (0.47) | CYP3A4SERPINE1SNCAALDH1A1HSD17B10 | |
| SCHEMBL8603488 | 0.82 | CYP3A4 (0.50) | CYP3A4SERPINE1SNCAALDH1A1HSD17B10 | |
| SCHEMBL7139650 | 0.80 | CA12 (0.53) | CYP3A4SERPINE1SNCAALDH1A1HSD17B10 | |
| SCHEMBL2967076 | 0.80 | CA12 (0.58) | CYP3A4SERPINE1SNCAALDH1A1HSD17B10 | |
| SCHEMBL6894689 | 0.80 | CYP3A4 (0.45) | CYP3A4SNCAALDH1A1HSD17B10TSHR | |
| SCHEMBL13337585 | 0.80 | CYP3A4 (0.45) | CYP3A4SERPINE1SNCAESR1KDM4E | |
| SCHEMBL2972468 | 0.79 | CA12 (0.62) | CYP3A4SNCAPTPN1ALDH1A1HSD17B10 | |
| SCHEMBL5416043 | 0.78 | SERPINE1 (0.53) | CYP3A4SERPINE1ESR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7435747-B2 | Guanidine and amidine derivatives as factor Xa inhibitors | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-10-14 | — | — | US | disclosed |
| EP-1345900-B1 | GUANIDINE AND AMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-01-17 | — | — | EP | disclosed |
| US-20050143419-A1 | Guanidine and amidine derivatives as factor Xa inhibitors | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-06-30 | — | — | US | disclosed |
| CN-1479722-A | Guanidine and amidine derivatives as factor Xa inhibitors | ���ĵ�˹ҩ��¹�����˾ | 2004-03-03 | — | — | CN | disclosed |
| EP-1345900-A1 | GUANIDINE AND AMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | Sanofi-Aventis Deutschland GmbH (DE) | 2003-09-24 | — | — | EP | disclosed |
| US-20020173656-A1 | Guanidine and amidine derivatives as factor Xa inhibitors | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-11-21 | — | — | US | disclosed |
| WO-2002046159-A1 | GUANIDINE AND AMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-06-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020173656-A1 | Guanidine and amidine derivatives as factor Xa inhibitors | F5, F9, F10 | CYP3A4 2013/4885SERPINE1 16/4885SNCA 1157/4885 |
| US-20050143419-A1 | Guanidine and amidine derivatives as factor Xa inhibitors | F5, F10, F12 | CYP3A4 2019/4885SERPINE1 18/4885SNCA 917/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.